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MTNR1B has not been detected as a mutational cancer driver

MTNR1B
Ensembl id ENSG00000134640
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 35 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MTNR1B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 9 9 5.17
Cutaneous melanoma No 11 8 2.17
Stomach adenocarcinoma No 5 4 2.48
Lung adenocarcinoma No 5 3 0.77
Esophageal carcinoma No 3 3 2.05
Uterine corpus endometrioid carcinoma No 3 2 0.87
Head and neck squamous cell carcinoma No 5 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 2 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Diffuse B cell lymphoma No 1 1 4.35
Breast carcinoma No 2 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence