MEGF6 has not been detected as a mutational cancer driver

Ensembl id ENSG00000162591
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 50 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MEGF6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 12 3.25
Renal clear cell carcinoma No 5 5 1.20
Bladder carcinoma No 4 4 4.08
Lung squamous cell carcinoma No 4 4 2.30
Head and neck squamous cell carcinoma No 7 4 1.07
Esophageal carcinoma No 4 4 2.74
Lung adenocarcinoma No 3 3 0.77
Uterine corpus endometrioid carcinoma No 4 3 1.30
Glioblastoma multiforme No 3 3 0.79
Breast carcinoma No 2 2 0.17
Thyroid carcinoma No 2 2 0.62
Chronic lymphocytic leukemia No 5 2 0.69
Stomach adenocarcinoma No 6 2 1.24
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence