MCM8 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

Ensembl id ENSG00000125885
Mutated samples
Coding Sequence 38 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MCM8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 11 10 2.71
Bladder carcinoma No 5 4 4.08
Lung squamous cell carcinoma No 5 4 2.30
Head and neck squamous cell carcinoma No 5 4 1.07
Stomach adenocarcinoma No 2 2 1.24
Esophageal carcinoma No 4 2 1.37
Uterine corpus endometrioid carcinoma No 1 1 0.43
Small cell lung carcinoma No 1 1 1.45
Prostate adenocarcinoma No 1 0 0.00
Lung adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence