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MAPT has not been detected as a mutational cancer driver

MAPT
Ensembl id ENSG00000186868
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 46 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAPT gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 13 3.52
Head and neck squamous cell carcinoma No 9 7 1.87
Lung adenocarcinoma No 8 6 1.53
Lung squamous cell carcinoma No 8 4 2.30
Uterine corpus endometrioid carcinoma No 9 4 1.74
Bladder carcinoma No 6 3 3.06
Breast carcinoma No 6 3 0.26
Stomach adenocarcinoma No 4 2 1.24
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Acute myeloid leukemia No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence