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MAP3K4 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

MAP3K4
Ensembl id ENSG00000085511
Mutated samples
Coding Sequence 93 (1.4%)
Protein Affecting 74 (1.1%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAP3K4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 20 16 4.34
Lung adenocarcinoma Yes 18 15 3.84
Bladder carcinoma Yes 4 4 4.08
Lung squamous cell carcinoma Yes 5 3 1.72
Colorectal adenocarcinoma Yes 4 3 1.31
Esophageal carcinoma Yes 3 3 2.05
Serous ovarian adenocarcinoma Yes 2 2 0.63
Glioblastoma multiforme Yes 2 2 0.53
Breast carcinoma No 9 6 0.52
Uterine corpus endometrioid carcinoma No 6 6 2.61
Head and neck squamous cell carcinoma No 6 5 1.33
Renal clear cell carcinoma No 5 4 0.96
Hepatocarcinoma No 1 1 1.11
Chronic lymphocytic leukemia No 3 1 0.34
Stomach adenocarcinoma No 2 1 0.62
Small cell lung carcinoma No 2 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence