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MAP3K15 has not been detected as a mutational cancer driver

MAP3K15
Ensembl id ENSG00000180815
Mutated samples
Coding Sequence 91 (1.3%)
Protein Affecting 54 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAP3K15 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 17 4.61
Lung adenocarcinoma No 9 6 1.53
Renal clear cell carcinoma No 7 5 1.20
Uterine corpus endometrioid carcinoma No 8 5 2.17
Breast carcinoma No 7 4 0.35
Serous ovarian adenocarcinoma No 3 3 0.95
Lung squamous cell carcinoma No 6 2 1.15
Stomach adenocarcinoma No 3 2 1.24
Colorectal adenocarcinoma No 4 2 0.87
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 1 1 1.45
Head and neck squamous cell carcinoma No 4 1 0.27
Esophageal carcinoma No 2 1 0.68
Bladder carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence