Top
LPHN2 is detected as a mutational cancer driver in 2 cancer types: Lung adenocarcinoma, Breast carcinoma and in the PAN-cancer analysis

LPHN2
Ensembl id ENSG00000117114
Mutated samples
Coding Sequence 210 (3.1%)
Protein Affecting 132 (1.9%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
LUAD R
BRCA CF
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LPHN2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 26 21 5.37
Breast carcinoma Yes 11 11 0.96
Head and neck squamous cell carcinoma Yes 8 8 2.13
Stomach adenocarcinoma Yes 9 5 3.11
Colorectal adenocarcinoma Yes 3 3 1.31
Renal clear cell carcinoma Yes 3 2 0.48
Serous ovarian adenocarcinoma Yes 2 2 0.63
Cutaneous melanoma No 74 42 11.38
Bladder carcinoma No 8 7 7.14
Lung squamous cell carcinoma No 8 7 4.02
Uterine corpus endometrioid carcinoma No 6 6 2.61
Esophageal carcinoma No 8 5 3.42
Multiple myeloma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 2 1 0.47
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 19 1 0.34
Lower grade glioma No 2 1 0.59
Small cell lung carcinoma No 1 1 1.45
Diffuse B cell lymphoma No 3 1 4.35
Glioblastoma multiforme No 2 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Non small cell lung carcinoma No 2 0 0.00
Pylocytic astrocytoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence