IntOGen - LIFR gene cancer mutations in SCLC

LIFR is detected as a mutational cancer driver in Small Cell Lung Cancer

LIFR reports in Small Cell Lung Cancer (SCLC)

Methods
Mutation distribution

Cancer type details

Small Cell Lung Cancer
Cohorts 3 Samples 188 Mutations 2,426,920 Driver genes 24

Gene details

LIFR
Ensembl ID ENSG00000113594 Transcript ID ENST00000453190 Protein ID ENSP00000398368
Cohorts where is driver 1 Mutated samples 4 Mutated samples (%) 2.13 Mutations 8
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence