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LAMA1 has not been detected as a mutational cancer driver

LAMA1
Ensembl id ENSG00000101680
Mutated samples
Coding Sequence 297 (4.4%)
Protein Affecting 205 (3.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LAMA1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 53 38 10.30
Lung adenocarcinoma No 34 26 6.65
Head and neck squamous cell carcinoma No 23 20 5.33
Stomach adenocarcinoma No 22 18 11.18
Esophageal carcinoma No 22 18 12.33
Lung squamous cell carcinoma No 19 14 8.05
Breast carcinoma No 19 12 1.05
Glioblastoma multiforme No 18 10 2.64
Colorectal adenocarcinoma No 14 9 3.93
Renal clear cell carcinoma No 10 6 1.44
Small cell lung carcinoma No 7 6 8.70
Uterine corpus endometrioid carcinoma No 8 5 2.17
Serous ovarian adenocarcinoma No 7 5 1.58
Bladder carcinoma No 6 3 3.06
Non small cell lung carcinoma No 3 3 9.68
Lower grade glioma No 5 3 1.78
Hepatocarcinoma No 5 2 2.22
Pancreas adenocarcinoma No 4 2 0.93
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Multiple myeloma No 4 1 1.45
Diffuse B cell lymphoma No 2 1 4.35
Medulloblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence