IntOGen - KRAS gene cancer mutations in NSCLC

KRAS is detected as a mutational cancer driver in Non-Small Cell Lung Cancer

KRAS reports in Non-Small Cell Lung Cancer (NSCLC)

Methods
Mutation distribution

Cancer type details

Non-Small Cell Lung Cancer
Cohorts 2 Samples 564 Mutations 22,065,649 Driver genes 48

Gene details

KRAS
Ensembl ID ENSG00000133703 Transcript ID ENST00000256078 Protein ID ENSP00000256078
Cohorts where is driver 2 Mutated samples 102 Mutated samples (%) 18.09 Mutations 104
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence