IRS2 mutations in 7 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Prostate adenocarcinoma, Lung adenocarcinoma, Bladder carcinoma, Lung squamous cell carcinoma, Stomach adenocarcinoma, Head and neck squamous cell carcinoma, Esophageal carcinoma

Ensembl id ENSG00000185950
Mutated samples
Coding Sequence 24 (0.4%)
Protein Affecting 19 (0.3%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all IRS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 3 3 1.86
Prostate adenocarcinoma Yes 2 2 0.82
Lung adenocarcinoma Yes 3 2 0.51
Bladder carcinoma Yes 2 2 2.04
Lung squamous cell carcinoma Yes 2 2 1.15
Head and neck squamous cell carcinoma Yes 2 2 0.53
Esophageal carcinoma Yes 2 2 1.37
Renal clear cell carcinoma No 1 1 0.24
Cutaneous melanoma No 2 1 0.27
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence