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IKZF1 is detected as a mutational cancer driver in Acute Myeloid Leukemia

IKZF1 reports in Acute Myeloid Leukemia (AML)

Cancer type details
Acute Myeloid Leukemia
Cohorts 9
Samples 661
Mutations 295,755
Driver genes 62
Gene details
IKZF1
Ensembl ID ENSG00000185811
Transcript ID ENST00000331340
Protein ID ENSP00000331614
Cohorts where is driver 1
Mutated samples 6
Mutated samples (%) 0.91
Mutations 7
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence