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H2AFX has not been detected as a mutational cancer driver

H2AFX
Ensembl id ENSG00000188486
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 7 (0.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all H2AFX gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 13 2 0.54
Lung adenocarcinoma No 5 1 0.26
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 6 1 0.09
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 2 1 1.45
Hepatocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Uterine corpus endometrioid carcinoma No 2 0 0.00
Stomach adenocarcinoma No 3 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence