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GUCY2C has not been detected as a mutational cancer driver

GUCY2C
Ensembl id ENSG00000070019
Mutated samples
Coding Sequence 110 (1.6%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GUCY2C gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 52 32 8.67
Breast carcinoma No 10 8 0.70
Lung adenocarcinoma No 6 6 1.53
Lung squamous cell carcinoma No 7 4 2.30
Uterine corpus endometrioid carcinoma No 4 3 1.30
Serous ovarian adenocarcinoma No 4 3 0.95
Hepatocarcinoma No 2 2 2.22
Bladder carcinoma No 2 2 2.04
Lower grade glioma No 2 2 1.18
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 2 1 0.68
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence