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GTF3C1 has not been detected as a mutational cancer driver

GTF3C1
Ensembl id ENSG00000077235
Mutated samples
Coding Sequence 151 (2.2%)
Protein Affecting 119 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GTF3C1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 43 31 8.40
Lung adenocarcinoma No 16 12 3.07
Stomach adenocarcinoma No 14 11 6.83
Breast carcinoma No 12 10 0.87
Head and neck squamous cell carcinoma No 14 10 2.67
Uterine corpus endometrioid carcinoma No 9 8 3.48
Colorectal adenocarcinoma No 6 6 2.62
Bladder carcinoma No 4 4 4.08
Lung squamous cell carcinoma No 7 4 2.30
Renal clear cell carcinoma No 5 4 0.96
Glioblastoma multiforme No 4 4 1.06
Esophageal carcinoma No 4 4 2.74
Medulloblastoma No 3 3 1.43
Serous ovarian adenocarcinoma No 3 3 0.95
Prostate adenocarcinoma No 3 2 0.82
Hepatocarcinoma No 1 1 1.11
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Pancreas adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence