Top
GRIN2B has not been detected as a mutational cancer driver

GRIN2B
Ensembl id ENSG00000150086
Mutated samples
Coding Sequence 262 (3.9%)
Protein Affecting 177 (2.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GRIN2B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 95 60 16.26
Lung adenocarcinoma No 26 21 5.37
Head and neck squamous cell carcinoma No 24 18 4.80
Lung squamous cell carcinoma No 20 14 8.05
Breast carcinoma No 16 11 0.96
Small cell lung carcinoma No 12 10 14.49
Uterine corpus endometrioid carcinoma No 8 6 2.61
Renal clear cell carcinoma No 7 5 1.20
Stomach adenocarcinoma No 5 5 3.11
Glioblastoma multiforme No 8 5 1.32
Lower grade glioma No 4 4 2.37
Esophageal carcinoma No 8 4 2.74
Prostate adenocarcinoma No 5 3 1.23
Serous ovarian adenocarcinoma No 4 3 0.95
Medulloblastoma No 4 2 0.95
Thyroid carcinoma No 2 2 0.62
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 6 1 0.34
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence