IntOGen - GPAA1 gene cancer mutations in BLCA

GPAA1 is detected as a mutational cancer driver in Bladder Urothelial Carcinoma

GPAA1 reports in Bladder Urothelial Carcinoma (BLCA)

Methods
Mutation distribution

Cancer type details

Bladder Urothelial Carcinoma
Cohorts 8 Samples 905 Mutations 6,585,575 Driver genes 89

Gene details

GPAA1
Ensembl ID ENSG00000197858 Transcript ID ENST00000355091 Protein ID ENSP00000347206
Cohorts where is driver 1 Mutated samples 5 Mutated samples (%) 0.55 Mutations 16
Mode of action Activating
Known driver False

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence