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FREM1 has not been detected as a mutational cancer driver

FREM1
Ensembl id ENSG00000164946
Mutated samples
Coding Sequence 193 (2.8%)
Protein Affecting 130 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FREM1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 65 45 12.20
Lung adenocarcinoma No 20 12 3.07
Lung squamous cell carcinoma No 15 10 5.75
Breast carcinoma No 14 9 0.78
Head and neck squamous cell carcinoma No 9 7 1.87
Esophageal carcinoma No 8 7 4.79
Uterine corpus endometrioid carcinoma No 8 6 2.61
Renal clear cell carcinoma No 7 5 1.20
Stomach adenocarcinoma No 7 5 3.11
Bladder carcinoma No 5 4 4.08
Serous ovarian adenocarcinoma No 4 4 1.27
Multiple myeloma No 4 3 4.35
Glioblastoma multiforme No 5 3 0.79
Thyroid carcinoma No 2 2 0.62
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Pancreas adenocarcinoma No 2 1 0.47
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 3 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence