FAT1 is detected as a mutational cancer driver in Head and Neck Squamous Cell Carcinoma
FAT1 reports in Head and Neck Squamous Cell Carcinoma (HNSC)
Cancer type details
Head and Neck Squamous Cell Carcinoma |
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Cohorts
6
Samples 818 Mutations 2,112,343 Driver genes 80 |
Gene details
FAT1 |
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Ensembl ID
ENSG00000083857
Transcript ID ENST00000441802 Protein ID ENSP00000406229 |
Cohorts where is driver
5
Mutated samples 148 Mutated samples (%) 18.09 Mutations 199 |
Mode of action Loss of function |
Known driver True |
Method signals per Cohort
Cohort | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
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HNSC (Head and Neck Squamous Cell Carcinoma) | 41283 | 1619 | 3.92 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Samples (%) | Consequence | Driver | Driver score |
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