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FANCM has not been detected as a mutational cancer driver

FANCM
Ensembl id ENSG00000187790
Mutated samples
Coding Sequence 111 (1.6%)
Protein Affecting 87 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FANCM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 19 16 4.09
Cutaneous melanoma No 20 13 3.52
Lung squamous cell carcinoma No 9 8 4.60
Uterine corpus endometrioid carcinoma No 9 8 3.48
Head and neck squamous cell carcinoma No 7 7 1.87
Breast carcinoma No 7 5 0.44
Stomach adenocarcinoma No 6 5 3.11
Glioblastoma multiforme No 4 4 1.06
Esophageal carcinoma No 5 4 2.74
Bladder carcinoma No 6 3 3.06
Renal clear cell carcinoma No 4 2 0.48
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 2 2 2.90
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 1 1 0.34
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Prostate adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence