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FAF1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

FAF1
Ensembl id ENSG00000185104
Mutated samples
Coding Sequence 46 (0.7%)
Protein Affecting 30 (0.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
CM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FAF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 10 9 2.44
Lung adenocarcinoma No 6 3 0.77
Breast carcinoma No 4 3 0.26
Stomach adenocarcinoma No 3 3 1.86
Prostate adenocarcinoma No 2 2 0.82
Head and neck squamous cell carcinoma No 2 2 0.53
Lung squamous cell carcinoma No 1 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Uterine corpus endometrioid carcinoma No 2 1 0.43
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Bladder carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence