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EZH2 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

EZH2
Ensembl id ENSG00000106462
Mutated samples
Coding Sequence 68 (1.0%)
Protein Affecting 59 (0.9%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EZH2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 19 18 4.88
Lung adenocarcinoma Yes 6 5 1.28
Lung squamous cell carcinoma Yes 7 4 2.30
Head and neck squamous cell carcinoma Yes 5 4 1.07
Acute myeloid leukemia Yes 3 3 1.53
Renal clear cell carcinoma Yes 3 3 0.72
Glioblastoma multiforme Yes 4 3 0.79
Esophageal carcinoma Yes 3 3 2.05
Stomach adenocarcinoma Yes 2 2 1.24
Uterine corpus endometrioid carcinoma No 4 4 1.74
Acute lymphocytic leukemia No 3 3 2.46
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 2 1 1.02
Breast carcinoma No 1 1 0.09
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence