IntOGen - EP300 gene cancer mutations in HNSC

EP300 is detected as a mutational cancer driver in Head and Neck Squamous Cell Carcinoma

EP300 reports in Head and Neck Squamous Cell Carcinoma (HNSC)

Methods
Mutation distribution

Cancer type details

Head and Neck Squamous Cell Carcinoma
Cohorts 6 Samples 818 Mutations 2,112,343 Driver genes 80

Gene details

EP300
Ensembl ID ENSG00000100393 Transcript ID ENST00000263253 Protein ID ENSP00000263253
Cohorts where is driver 3 Mutated samples 37 Mutated samples (%) 4.52 Mutations 52
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence