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EIF2AK4 has not been detected as a mutational cancer driver

EIF2AK4
Ensembl id ENSG00000128829
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 63 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EIF2AK4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 28 18 4.88
Breast carcinoma No 8 7 0.61
Lung squamous cell carcinoma No 6 6 3.45
Head and neck squamous cell carcinoma No 9 6 1.60
Lung adenocarcinoma No 5 5 1.28
Stomach adenocarcinoma No 7 4 2.48
Bladder carcinoma No 4 3 3.06
Renal clear cell carcinoma No 4 3 0.72
Uterine corpus endometrioid carcinoma No 3 2 0.87
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 3 1 3.23
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Prostate adenocarcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence