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DYNC2H1 has not been detected as a mutational cancer driver

DYNC2H1
Ensembl id ENSG00000187240
Mutated samples
Coding Sequence 198 (2.9%)
Protein Affecting 155 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DYNC2H1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 36 32 8.67
Breast carcinoma No 21 18 1.57
Stomach adenocarcinoma No 19 14 8.70
Head and neck squamous cell carcinoma No 17 14 3.73
Lung adenocarcinoma No 18 13 3.32
Esophageal carcinoma No 12 10 6.85
Uterine corpus endometrioid carcinoma No 14 9 3.91
Renal clear cell carcinoma No 10 8 1.92
Lung squamous cell carcinoma No 6 6 3.45
Colorectal adenocarcinoma No 6 6 2.62
Bladder carcinoma No 5 5 5.10
Multiple myeloma No 4 4 5.80
Hepatocarcinoma No 6 3 3.33
Thyroid carcinoma No 3 2 0.62
Chronic lymphocytic leukemia No 6 2 0.69
Serous ovarian adenocarcinoma No 4 2 0.63
Glioblastoma multiforme No 3 2 0.53
Acute myeloid leukemia No 2 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Lower grade glioma No 2 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence