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DPP6 has not been detected as a mutational cancer driver

DPP6
Ensembl id ENSG00000130226
Mutated samples
Coding Sequence 145 (2.1%)
Protein Affecting 85 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DPP6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 19 5.15
Head and neck squamous cell carcinoma No 18 14 3.73
Lung squamous cell carcinoma No 15 12 6.90
Lung adenocarcinoma No 13 9 2.30
Breast carcinoma No 9 6 0.52
Pancreas adenocarcinoma No 4 4 1.87
Uterine corpus endometrioid carcinoma No 4 4 1.74
Prostate adenocarcinoma No 4 3 1.23
Stomach adenocarcinoma No 4 3 1.86
Renal clear cell carcinoma No 2 2 0.48
Colorectal adenocarcinoma No 2 2 0.87
Hepatocarcinoma No 6 1 1.11
Bladder carcinoma No 2 1 1.02
Chronic lymphocytic leukemia No 21 1 0.34
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Pylocytic astrocytoma No 3 0 0.00
Esophageal carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence