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DMXL2 has not been detected as a mutational cancer driver

DMXL2
Ensembl id ENSG00000104093
Mutated samples
Coding Sequence 149 (2.2%)
Protein Affecting 114 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DMXL2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 41 26 7.05
Breast carcinoma No 14 11 0.96
Bladder carcinoma No 10 9 9.18
Stomach adenocarcinoma No 11 8 4.97
Head and neck squamous cell carcinoma No 9 8 2.13
Lung adenocarcinoma No 8 7 1.79
Lung squamous cell carcinoma No 8 7 4.02
Renal clear cell carcinoma No 7 7 1.68
Serous ovarian adenocarcinoma No 7 6 1.90
Colorectal adenocarcinoma No 5 5 2.18
Uterine corpus endometrioid carcinoma No 5 4 1.74
Prostate adenocarcinoma No 3 3 1.23
Chronic lymphocytic leukemia No 5 3 1.03
Esophageal carcinoma No 3 3 2.05
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 3 2 1.18
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence