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DMC1 has not been detected as a mutational cancer driver

DMC1
Ensembl id ENSG00000100206
Mutated samples
Coding Sequence 27 (0.4%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DMC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 10 10 2.71
Head and neck squamous cell carcinoma No 3 3 0.80
Breast carcinoma No 2 2 0.17
Small cell lung carcinoma No 2 2 2.90
Lung adenocarcinoma No 1 1 0.26
Hepatocarcinoma No 1 1 1.11
Lung squamous cell carcinoma No 1 1 0.57
Uterine corpus endometrioid carcinoma No 2 1 0.43
Lower grade glioma No 1 1 0.59
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence