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DHX15 mutations in 7 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Breast carcinoma, Lung squamous cell carcinoma, Renal clear cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma

DHX15
Ensembl id ENSG00000109606
Mutated samples
Coding Sequence 50 (0.7%)
Protein Affecting 31 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DHX15 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 12 7 1.90
Breast carcinoma Yes 5 5 0.44
Lung adenocarcinoma Yes 4 3 0.77
Lung squamous cell carcinoma Yes 3 3 1.72
Uterine corpus endometrioid carcinoma Yes 5 3 1.30
Stomach adenocarcinoma Yes 5 3 1.86
Renal clear cell carcinoma Yes 4 2 0.48
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Serous ovarian adenocarcinoma No 1 1 0.32
Head and neck squamous cell carcinoma No 3 1 0.27
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 3 0 0.00
Multiple myeloma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence