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CYP4F12 has not been detected as a mutational cancer driver

CYP4F12
Ensembl id ENSG00000186204
Mutated samples
Coding Sequence 113 (1.7%)
Protein Affecting 74 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CYP4F12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 54 28 7.59
Lung adenocarcinoma No 10 9 2.30
Head and neck squamous cell carcinoma No 7 6 1.60
Lung squamous cell carcinoma No 5 5 2.87
Glioblastoma multiforme No 6 5 1.32
Breast carcinoma No 5 4 0.35
Uterine corpus endometrioid carcinoma No 5 4 1.74
Bladder carcinoma No 4 3 3.06
Serous ovarian adenocarcinoma No 3 3 0.95
Prostate adenocarcinoma No 2 2 0.82
Renal clear cell carcinoma No 2 2 0.48
Acute myeloid leukemia No 1 1 0.51
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Medulloblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
Stomach adenocarcinoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence