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CTNNB1 is detected as a mutational cancer driver in 7 cancer types: Prostate adenocarcinoma, Hepatocarcinoma, Medulloblastoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma plus in 1 more and in the PAN-cancer analysis

CTNNB1
Ensembl id ENSG00000168036
Mutated samples
Coding Sequence 199 (2.9%)
Protein Affecting 184 (2.7%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
PRAD CF
HC C
MB CF
CM F
UCEC FR
STAD F
COREAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CTNNB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 66 65 28.26
Medulloblastoma Yes 26 26 12.38
Cutaneous melanoma Yes 24 19 5.15
Hepatocarcinoma Yes 19 17 18.89
Lung adenocarcinoma Yes 10 10 2.56
Stomach adenocarcinoma Yes 11 10 6.21
Prostate adenocarcinoma Yes 9 9 3.70
Colorectal adenocarcinoma Yes 9 9 3.93
Lung squamous cell carcinoma Yes 4 3 1.72
Esophageal carcinoma Yes 3 3 2.05
Bladder carcinoma Yes 2 2 2.04
Thyroid carcinoma Yes 2 2 0.62
Serous ovarian adenocarcinoma Yes 3 2 0.63
Head and neck squamous cell carcinoma Yes 4 2 0.53
Breast carcinoma No 4 2 0.17
Renal clear cell carcinoma No 1 1 0.24
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence