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CNTNAP2 has not been detected as a mutational cancer driver

CNTNAP2
Ensembl id ENSG00000174469
Mutated samples
Coding Sequence 338 (5.0%)
Protein Affecting 221 (3.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CNTNAP2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 97 67 18.16
Lung adenocarcinoma No 32 28 7.16
Head and neck squamous cell carcinoma No 26 23 6.13
Lung squamous cell carcinoma No 31 22 12.64
Glioblastoma multiforme No 18 14 3.69
Uterine corpus endometrioid carcinoma No 12 11 4.78
Stomach adenocarcinoma No 16 9 5.59
Serous ovarian adenocarcinoma No 8 8 2.53
Colorectal adenocarcinoma No 7 7 3.06
Breast carcinoma No 9 6 0.52
Small cell lung carcinoma No 7 6 8.70
Bladder carcinoma No 7 5 5.10
Esophageal carcinoma No 7 5 3.42
Renal clear cell carcinoma No 6 4 0.96
Neuroblastoma No 2 2 0.95
Lower grade glioma No 2 2 1.18
Pancreas adenocarcinoma No 2 1 0.47
Chronic lymphocytic leukemia No 25 1 0.34
Hepatocarcinoma No 6 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 17 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence