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CNOT1 mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Prostate adenocarcinoma, Hepatocarcinoma, Bladder carcinoma, Stomach adenocarcinoma, Colorectal adenocarcinoma, Glioblastoma multiforme, Esophageal carcinoma, Acute lymphocytic leukemia

CNOT1
Ensembl id ENSG00000125107
Mutated samples
Coding Sequence 151 (2.2%)
Protein Affecting 99 (1.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CNOT1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder carcinoma Yes 7 3 3.06
Stomach adenocarcinoma Yes 9 3 1.86
Colorectal adenocarcinoma Yes 4 3 1.31
Glioblastoma multiforme Yes 5 3 0.79
Esophageal carcinoma Yes 5 3 2.05
Prostate adenocarcinoma Yes 3 2 0.82
Hepatocarcinoma Yes 2 2 2.22
Acute lymphocytic leukemia Yes 2 2 1.64
Cutaneous melanoma No 31 21 5.69
Head and neck squamous cell carcinoma No 17 11 2.93
Uterine corpus endometrioid carcinoma No 10 10 4.35
Renal clear cell carcinoma No 12 8 1.92
Lung adenocarcinoma No 13 7 1.79
Lung squamous cell carcinoma No 6 6 3.45
Breast carcinoma No 10 5 0.44
Serous ovarian adenocarcinoma No 5 4 1.27
Small cell lung carcinoma No 2 2 2.90
Thyroid carcinoma No 2 1 0.31
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 2 1 0.34
Lower grade glioma No 2 1 0.59
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence