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CHD8 is detected as a mutational cancer driver in 1 Glioblastoma multiforme project

Glioblastoma multiforme
Projects 2
379 Samples
Coding sequence mutations (CSMs)
in driver genes 842
in all genes 34259
Protein affecting mutations (PAMs)
in driver genes 766
in all genes 17598
CHD8
Ensembl id ENSG00000100888
Mutated samples
Coding Sequence 10 (2.6%)
Protein Affecting 10 (2.6%)
Mode of action Loss of function
Known driver No
Project Signals
GBM_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Glioblastoma multiforme projects in all CHD8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Glioblastoma multiforme TCGA Yes 10 10 2.64
The mutations needle plot shows the distribution of the observed CHD8 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification