IntOGen - CDKN2A gene cancer mutations in ESCA

CDKN2A is detected as a mutational cancer driver in Esophageal Adenocarcinoma

CDKN2A reports in Esophageal Adenocarcinoma (ESCA)

Methods
Mutation distribution

Cancer type details

Esophageal Adenocarcinoma
Cohorts 8 Samples 1,139 Mutations 17,905,104 Driver genes 90

Gene details

CDKN2A
Ensembl ID ENSG00000147889 Transcript ID ENST00000498124 Protein ID ENSP00000418915
Cohorts where is driver 7 Mutated samples 102 Mutated samples (%) 8.96 Mutations 131
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence