CDKN2A is detected as a mutational cancer driver in 1 Esophageal carcinoma project

Esophageal carcinoma
Projects 1
146 Samples
Coding sequence mutations (CSMs)
in driver genes 455
in all genes 40925
Protein affecting mutations (PAMs)
in driver genes 368
in all genes 17832
Ensembl id ENSG00000147889
Mutated samples
Coding Sequence 18 (12.3%)
Protein Affecting 15 (10.3%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Esophageal carcinoma projects in all CDKN2A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Esophagea cancer Dana Farber Cancer Institute obtained from AlexandrovEtAl Yes 18 15 10.27
The mutations needle plot shows the distribution of the observed CDKN2A cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification