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CDH5 has not been detected as a mutational cancer driver

CDH5
Ensembl id ENSG00000179776
Mutated samples
Coding Sequence 74 (1.1%)
Protein Affecting 56 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CDH5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 16 4.34
Head and neck squamous cell carcinoma No 9 7 1.87
Lung adenocarcinoma No 7 5 1.28
Lung squamous cell carcinoma No 4 4 2.30
Glioblastoma multiforme No 4 4 1.06
Prostate adenocarcinoma No 3 3 1.23
Chronic lymphocytic leukemia No 3 3 1.03
Stomach adenocarcinoma No 6 3 1.86
Neuroblastoma No 3 2 0.95
Serous ovarian adenocarcinoma No 2 2 0.63
Bladder carcinoma No 3 1 1.02
Breast carcinoma No 1 1 0.09
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 4 1 0.43
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence