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CDH23 has not been detected as a mutational cancer driver

CDH23
Ensembl id ENSG00000107736
Mutated samples
Coding Sequence 239 (3.5%)
Protein Affecting 149 (2.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CDH23 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 64 37 10.03
Lung adenocarcinoma No 27 21 5.37
Lung squamous cell carcinoma No 17 12 6.90
Uterine corpus endometrioid carcinoma No 16 12 5.22
Breast carcinoma No 12 9 0.78
Renal clear cell carcinoma No 12 8 1.92
Stomach adenocarcinoma No 14 8 4.97
Esophageal carcinoma No 8 7 4.79
Bladder carcinoma No 6 4 4.08
Head and neck squamous cell carcinoma No 12 4 1.07
Glioblastoma multiforme No 7 4 1.06
Prostate adenocarcinoma No 9 3 1.23
Lower grade glioma No 3 3 1.78
Colorectal adenocarcinoma No 5 3 1.31
Pancreas adenocarcinoma No 2 2 0.93
Neuroblastoma No 3 2 0.95
Chronic lymphocytic leukemia No 5 2 0.69
Serous ovarian adenocarcinoma No 3 2 0.63
Hepatocarcinoma No 4 1 1.11
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 2 1 0.48
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence