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ATP2B2 has not been detected as a mutational cancer driver

ATP2B2
Ensembl id ENSG00000157087
Mutated samples
Coding Sequence 156 (2.3%)
Protein Affecting 102 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP2B2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 55 32 8.67
Lung adenocarcinoma No 13 9 2.30
Stomach adenocarcinoma No 11 8 4.97
Breast carcinoma No 11 7 0.61
Lung squamous cell carcinoma No 9 7 4.02
Uterine corpus endometrioid carcinoma No 6 5 2.17
Colorectal adenocarcinoma No 7 5 2.18
Glioblastoma multiforme No 6 5 1.32
Serous ovarian adenocarcinoma No 5 4 1.27
Prostate adenocarcinoma No 4 3 1.23
Bladder carcinoma No 5 3 3.06
Head and neck squamous cell carcinoma No 5 3 0.80
Esophageal carcinoma No 4 3 2.05
Small cell lung carcinoma No 2 2 2.90
Hepatocarcinoma No 2 1 1.11
Acute myeloid leukemia No 1 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Lower grade glioma No 2 1 0.59
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence