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ATP2A1 has not been detected as a mutational cancer driver

ATP2A1
Ensembl id ENSG00000196296
Mutated samples
Coding Sequence 85 (1.3%)
Protein Affecting 55 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ATP2A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 12 3.25
Renal clear cell carcinoma No 8 6 1.44
Bladder carcinoma No 7 5 5.10
Breast carcinoma No 7 5 0.44
Lung adenocarcinoma No 7 4 1.02
Uterine corpus endometrioid carcinoma No 6 4 1.74
Head and neck squamous cell carcinoma No 5 4 1.07
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 3 2 0.63
Stomach adenocarcinoma No 5 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Esophageal carcinoma No 4 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 2 1 0.57
Chronic lymphocytic leukemia No 2 1 0.34
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence