IntOGen - ARID1A gene cancer mutations in LUAD

ARID1A is detected as a mutational cancer driver in Lung Adenocarcinoma

ARID1A reports in Lung Adenocarcinoma (LUAD)

Methods
Mutation distribution

Cancer type details

Lung Adenocarcinoma
Cohorts 6 Samples 1,215 Mutations 1,839,527 Driver genes 76

Gene details

ARID1A
Ensembl ID ENSG00000117713 Transcript ID ENST00000324856 Protein ID ENSP00000320485
Cohorts where is driver 2 Mutated samples 36 Mutated samples (%) 2.96 Mutations 62
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence