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ANGPT2 has not been detected as a mutational cancer driver

ANGPT2
Ensembl id ENSG00000091879
Mutated samples
Coding Sequence 41 (0.6%)
Protein Affecting 27 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ANGPT2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 9 6 1.63
Lung adenocarcinoma No 5 4 1.02
Esophageal carcinoma No 3 3 2.05
Breast carcinoma No 2 2 0.17
Uterine corpus endometrioid carcinoma No 4 2 0.87
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 2 1 1.02
Lung squamous cell carcinoma No 1 1 0.57
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 2 1 0.34
Head and neck squamous cell carcinoma No 2 1 0.27
Medulloblastoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence