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ADAM28 has not been detected as a mutational cancer driver

ADAM28
Ensembl id ENSG00000042980
Mutated samples
Coding Sequence 106 (1.6%)
Protein Affecting 71 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ADAM28 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 67 44 11.92
Head and neck squamous cell carcinoma No 6 5 1.33
Lung adenocarcinoma No 4 4 1.02
Glioblastoma multiforme No 9 4 1.06
Stomach adenocarcinoma No 3 3 1.86
Renal clear cell carcinoma No 2 2 0.48
Lower grade glioma No 3 2 1.18
Hepatocarcinoma No 2 1 1.11
Breast carcinoma No 1 1 0.09
Neuroblastoma No 2 1 0.48
Uterine corpus endometrioid carcinoma No 1 1 0.43
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 1 0 0.00
Bladder carcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence