DNMT3A is detected as a mutational cancer driver
DNMT3A reports
Gene details
DNMT3A |
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Ensembl ID
ENSG00000119772
Transcript ID ENST00000264709 Protein ID ENSP00000264709 |
Cancer types where is driver
7
Cohorts where is driver 11 Mutated samples 84 Mutations 397 |
Mode of action Loss of function |
Known driver True |
Method signals per Cancer Type
Cancer type | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
---|---|---|---|
AML (Acute myeloid leukemia) | 36 | 27 | 75.00 |
L (Lymphoid cancer) | 4 | 0 | 0.00 |
LK (Leukemia) | 2 | 1 | 50.00 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Consequence |
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