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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
NFE2L2 UCEC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
2:177234217:C R34G missense_variant 1.00 7
2:177234071:A E82D missense_variant 0.98 6
2:177234076:T G81S missense_variant 0.99 2
2:177234075:A G81V missense_variant 0.99 1
2:177234076:A G81C missense_variant 0.99 1
2:177234079:G T80P missense_variant 0.99 1
2:177234078:C T80R missense_variant 0.99 1
2:177234232:G D29H missense_variant 0.95 1
2:177234241:T Q26K missense_variant 0.95 1
2:177231257:T R449H missense_variant 0.82 1
2:177231672:T E311K missense_variant 0.76 1
2:177230916:T E563K missense_variant 0.70 1
2:177234190:C R43G missense_variant 0.53 1
2:177234073:G E82Q missense_variant 0.99 0
2:177234075:G G81A missense_variant 0.99 0
2:177234075:T G81D missense_variant 0.99 0
2:177234073:T E82K missense_variant 0.99 0
2:177234076:G G81R missense_variant 0.99 0
2:177234239:G Q26H missense_variant 0.99 0
2:177234239:A Q26H missense_variant 0.99 0
2:177234079:A T80S missense_variant 0.99 0
2:177234072:G E82A missense_variant 0.99 0
2:177234079:C T80A missense_variant 0.99 0
2:177234072:C E82G missense_variant 0.99 0
2:177234072:A E82V missense_variant 0.99 0
2:177234078:A T80I missense_variant 0.99 0
2:177234078:T T80K missense_variant 0.99 0
2:177234071:G E82D missense_variant 0.98 0
2:177234225:T G31E missense_variant 0.97 0
2:177234225:G G31A missense_variant 0.97 0
2:177234225:A G31V missense_variant 0.97 0
2:177234244:A R25W missense_variant 0.97 0
2:177234244:C R25G missense_variant 0.97 0
2:177234236:C D27E missense_variant 0.97 0
2:177234236:T D27E missense_variant 0.97 0
2:177234243:A R25M missense_variant 0.96 0
2:177234243:G R25T missense_variant 0.96 0
2:177234243:T R25K missense_variant 0.96 0
2:177234235:G I28L missense_variant 0.96 0
2:177234235:C I28V missense_variant 0.96 0
2:177234235:A I28L missense_variant 0.96 0
2:177234222:G V32A missense_variant 0.95 0
2:177234222:C V32G missense_variant 0.95 0
2:177234222:T V32E missense_variant 0.95 0
2:177234217:A R34* stop_gained 0.95 0
2:177234216:G R34P missense_variant 0.95 0
2:177234238:T D27N missense_variant 0.95 0
2:177234238:G D27H missense_variant 0.95 0
2:177234238:A D27Y missense_variant 0.95 0
2:177234245:A W24C missense_variant 0.95 0
2:177234223:A V32L missense_variant 0.95 0
2:177234223:G V32L missense_variant 0.95 0
2:177234223:T V32I missense_variant 0.95 0
2:177234245:G W24C missense_variant 0.95 0
2:177234219:T S33N missense_variant 0.95 0
2:177234219:G S33T missense_variant 0.95 0
2:177234219:A S33I missense_variant 0.95 0
2:177234226:G G31R missense_variant 0.95 0
2:177234216:T R34Q missense_variant 0.95 0
2:177234232:A D29Y missense_variant 0.95 0
2:177234226:T G31R missense_variant 0.95 0
2:177234216:A R34L missense_variant 0.95 0
2:177234232:T D29N missense_variant 0.95 0
2:177234240:G Q26P missense_variant 0.95 0
2:177234231:A D29V missense_variant 0.95 0
2:177234231:C D29G missense_variant 0.95 0
2:177234237:G D27A missense_variant 0.95 0
2:177234240:A Q26L missense_variant 0.95 0
2:177234237:C D27G missense_variant 0.95 0
2:177234237:A D27V missense_variant 0.95 0
2:177234231:G D29A missense_variant 0.95 0
2:177234240:C Q26R missense_variant 0.95 0
2:177234228:G L30P missense_variant 0.95 0
2:177234241:C Q26E missense_variant 0.95 0
2:177234234:T I28K missense_variant 0.95 0
2:177234234:G I28T missense_variant 0.95 0
2:177234234:C I28R missense_variant 0.95 0
2:177234229:T L30I missense_variant 0.95 0
2:177234229:C L30V missense_variant 0.95 0
2:177234229:A L30F missense_variant 0.95 0
2:177234228:T L30H missense_variant 0.95 0
2:177234228:C L30R missense_variant 0.95 0
2:177234073:A E82* stop_gained 0.93 0
2:177234246:A W24L missense_variant 0.93 0
2:177234246:G W24S missense_variant 0.93 0
2:177234082:T E79K missense_variant 0.93 0
2:177234082:G E79Q missense_variant 0.93 0
2:177234081:G E79A missense_variant 0.93 0
2:177234081:C E79G missense_variant 0.93 0
2:177234081:A E79V missense_variant 0.93 0
2:177234247:C W24G missense_variant 0.93 0
2:177234247:T W24R missense_variant 0.93 0
2:177234247:G W24R missense_variant 0.93 0
2:177231974:A T210I missense_variant 0.83 0
2:177231974:C T210S missense_variant 0.83 0
2:177231974:T T210N missense_variant 0.83 0
2:177234141:A Q59L missense_variant 0.83 0
2:177234141:C Q59R missense_variant 0.83 0
2:177234141:G Q59P missense_variant 0.83 0
2:177231618:A N329Y missense_variant 0.82 0
2:177231257:G R449P missense_variant 0.82 0
2:177234130:C Q63E missense_variant 0.82 0
2:177234130:T Q63K missense_variant 0.82 0
2:177234193:C R42G missense_variant 0.82 0
2:177234091:T L76I missense_variant 0.82 0
2:177234091:C L76V missense_variant 0.82 0
2:177231257:A R449L missense_variant 0.82 0
2:177231618:C N329D missense_variant 0.82 0
2:177231618:G N329H missense_variant 0.82 0
2:177234143:G R58S missense_variant 0.82 0
2:177234143:A R58S missense_variant 0.82 0
2:177234162:G K52T missense_variant 0.80 0
2:177231160:T F481L missense_variant 0.80 0
2:177230809:G K598N missense_variant 0.80 0
2:177230809:A K598N missense_variant 0.80 0
2:177231160:C F481L missense_variant 0.80 0
2:177230970:T E545K missense_variant 0.80 0
2:177230970:G E545Q missense_variant 0.80 0
2:177234162:C K52R missense_variant 0.80 0
2:177234162:A K52I missense_variant 0.80 0
2:177231864:T L247I missense_variant 0.80 0
2:177231864:C L247V missense_variant 0.80 0
2:177231864:A L247F missense_variant 0.80 0
2:177232439:A D183Y missense_variant 0.79 0
2:177232439:T D183N missense_variant 0.79 0
2:177232439:G D183H missense_variant 0.79 0
2:177233283:G L123F missense_variant 0.78 0
2:177233283:A L123F missense_variant 0.78 0
2:177231408:G S399P missense_variant 0.77 0
2:177231408:T S399T missense_variant 0.77 0
2:177231408:C S399A missense_variant 0.77 0
2:177234126:A K64M missense_variant 0.77 0
2:177230856:T L583M missense_variant 0.77 0
2:177234126:C K64R missense_variant 0.77 0
2:177230856:C L583V missense_variant 0.77 0
2:177234126:G K64T missense_variant 0.77 0
2:177231407:T S399Y missense_variant 0.77 0
2:177231407:C S399C missense_variant 0.77 0
2:177231407:A S399F missense_variant 0.77 0
2:177231012:A H531Y missense_variant 0.77 0
2:177231012:T H531N missense_variant 0.77 0
2:177231012:C H531D missense_variant 0.77 0
2:177231672:G E311Q missense_variant 0.76 0
2:177264557:T P7Q missense_variant 0.76 0
2:177232529:C S153G missense_variant 0.76 0
2:177232529:G S153R missense_variant 0.76 0
2:177264557:C P7R missense_variant 0.76 0
2:177232529:A S153C missense_variant 0.76 0
2:177264557:A P7L missense_variant 0.76 0
2:177231660:A G315W missense_variant 0.76 0
2:177231660:G G315R missense_variant 0.76 0
2:177231660:T G315R missense_variant 0.76 0
2:177234140:A Q59H missense_variant 0.76 0
2:177234140:G Q59H missense_variant 0.76 0
2:177230908:C F565L missense_variant 0.76 0
2:177230908:T F565L missense_variant 0.76 0
2:177234180:C Y46C missense_variant 0.76 0
2:177234180:G Y46S missense_variant 0.76 0
2:177232564:C Q141R missense_variant 0.76 0
2:177234180:A Y46F missense_variant 0.76 0
2:177232564:A Q141L missense_variant 0.76 0
2:177232564:G Q141P missense_variant 0.76 0
2:177231837:C S256G missense_variant 0.75 0
2:177231837:G S256R missense_variant 0.75 0
2:177231837:A S256C missense_variant 0.75 0
2:177233294:C M120V missense_variant 0.75 0
2:177233294:G M120L missense_variant 0.75 0
2:177233294:A M120L missense_variant 0.75 0
2:177231701:A S301L missense_variant 0.74 0
2:177232495:A S164L missense_variant 0.74 0
2:177230810:A K598M missense_variant 0.74 0
2:177230810:G K598T missense_variant 0.74 0
2:177230810:C K598R missense_variant 0.74 0
2:177234226:A G31* stop_gained 0.72 0
2:177234245:T W24* stop_gained 0.72 0
2:177231828:C S259A missense_variant 0.72 0
2:177231828:T S259T missense_variant 0.72 0
2:177231828:G S259P missense_variant 0.72 0
2:177232426:T V187D missense_variant 0.72 0
2:177231815:A P263L missense_variant 0.72 0
2:177231815:C P263R missense_variant 0.72 0
2:177231815:T P263H missense_variant 0.72 0
2:177232426:G V187A missense_variant 0.72 0
2:177232426:C V187G missense_variant 0.72 0
2:177232567:G F140S missense_variant 0.72 0
2:177232567:C F140C missense_variant 0.72 0
2:177232567:T F140Y missense_variant 0.72 0
2:177231545:G S353T missense_variant 0.72 0
2:177231545:A S353I missense_variant 0.72 0
2:177231545:T S353N missense_variant 0.72 0
2:177234241:A Q26* stop_gained 0.71 0
2:177234242:A R25S missense_variant 0.71 0
2:177234242:G R25S missense_variant 0.71 0
2:177231435:C Q390E missense_variant 0.71 0
2:177264537:T Q14K missense_variant 0.71 0
2:177231435:T Q390K missense_variant 0.71 0
2:177231758:A G282V missense_variant 0.71 0
2:177231758:G G282A missense_variant 0.71 0
2:177231758:T G282D missense_variant 0.71 0
2:177264537:C Q14E missense_variant 0.71 0
2:177233330:C I108V missense_variant 0.71 0
2:177233330:A I108F missense_variant 0.71 0
2:177233330:G I108L missense_variant 0.71 0
2:177233339:T V105I missense_variant 0.71 0
2:177231992:A N204I missense_variant 0.71 0
2:177231992:C N204S missense_variant 0.71 0
2:177231992:G N204T missense_variant 0.71 0
2:177232429:C Q186R missense_variant 0.71 0
2:177232429:G Q186P missense_variant 0.71 0
2:177231235:A R456S missense_variant 0.71 0
2:177233339:G V105L missense_variant 0.71 0
2:177233339:A V105F missense_variant 0.71 0
2:177231235:G R456S missense_variant 0.71 0
2:177232429:A Q186L missense_variant 0.71 0
2:177231181:C I474M missense_variant 0.71 0
2:177234041:C I92M missense_variant 0.71 0
2:177234260:G L19F missense_variant 0.71 0
2:177234260:A L19F missense_variant 0.71 0
2:177231822:G E261Q missense_variant 0.70 0
2:177230868:C S579G missense_variant 0.70 0
2:177230868:A S579C missense_variant 0.70 0
2:177231822:T E261K missense_variant 0.70 0
2:177230843:A R587I missense_variant 0.70 0
2:177230868:G S579R missense_variant 0.70 0
2:177230843:T R587K missense_variant 0.70 0
2:177230843:G R587T missense_variant 0.70 0
2:177231809:A Q265L missense_variant 0.70 0
2:177230916:G E563Q missense_variant 0.70 0
2:177231809:C Q265R missense_variant 0.70 0
2:177231809:G Q265P missense_variant 0.70 0
2:177231948:G K219Q missense_variant 0.70 0
2:177231843:T F254I missense_variant 0.70 0
2:177231843:G F254L missense_variant 0.70 0
2:177231843:C F254V missense_variant 0.70 0
2:177231948:C K219E missense_variant 0.70 0
2:177234220:A S33C missense_variant 0.70 0
2:177234220:G S33R missense_variant 0.70 0
2:177234220:C S33G missense_variant 0.70 0
2:177233264:A V130L missense_variant 0.70 0
2:177233264:T V130I missense_variant 0.70 0
2:177233264:G V130L missense_variant 0.70 0
2:177232576:A S137L missense_variant 0.70 0
2:177232576:C S137W missense_variant 0.70 0
2:177231296:G H436P missense_variant 0.70 0
2:177231296:C H436R missense_variant 0.70 0
2:177231296:A H436L missense_variant 0.70 0
2:177231875:T S243N missense_variant 0.70 0
2:177231875:G S243T missense_variant 0.70 0
2:177231875:A S243I missense_variant 0.70 0
2:177231494:C L370R missense_variant 0.70 0
2:177231494:T L370Q missense_variant 0.70 0
2:177231494:G L370P missense_variant 0.70 0
2:177234230:C D29E missense_variant 0.70 0
2:177234230:T D29E missense_variant 0.70 0
2:177234025:T G98R missense_variant 0.70 0
2:177234025:G G98R missense_variant 0.70 0
2:177234218:C S33R missense_variant 0.70 0
2:177234218:T S33R missense_variant 0.70 0
2:177234233:C I28M missense_variant 0.70 0
2:177232573:A A138V missense_variant 0.69 0
2:177232573:T A138D missense_variant 0.69 0
2:177232583:A V135F missense_variant 0.69 0
2:177232421:T E189K missense_variant 0.69 0
2:177232421:G E189Q missense_variant 0.69 0
2:177232573:C A138G missense_variant 0.69 0
2:177232583:T V135I missense_variant 0.69 0
2:177232583:G V135L missense_variant 0.69 0
2:177230968:A E545D missense_variant 0.69 0
2:177231326:T P426Q missense_variant 0.69 0
2:177231326:C P426R missense_variant 0.69 0
2:177231326:A P426L missense_variant 0.69 0
2:177230968:G E545D missense_variant 0.69 0
2:177231773:C V277G missense_variant 0.69 0
2:177231773:G V277A missense_variant 0.69 0
2:177231773:T V277D missense_variant 0.69 0
2:177231324:T E427K missense_variant 0.69 0
2:177231324:G E427Q missense_variant 0.69 0
2:177230905:C S566R missense_variant 0.69 0
2:177230905:T S566R missense_variant 0.69 0
2:177231957:A P216S missense_variant 0.69 0
2:177231957:C P216A missense_variant 0.69 0
2:177231957:T P216T missense_variant 0.69 0
2:177231558:C N349D missense_variant 0.69 0
2:177231558:G N349H missense_variant 0.69 0
2:177231558:A N349Y missense_variant 0.69 0
2:177231729:T E292K missense_variant 0.68 0
2:177231729:G E292Q missense_variant 0.68 0
2:177231380:A S408L missense_variant 0.67 0
2:177231023:A Q527L missense_variant 0.67 0
2:177231023:G Q527P missense_variant 0.67 0
2:177231023:C Q527R missense_variant 0.67 0
2:177231232:C D457E missense_variant 0.67 0
2:177234034:G E95Q missense_variant 0.67 0
2:177234034:T E95K missense_variant 0.67 0
2:177231232:T D457E missense_variant 0.67 0
2:177231593:A A337V missense_variant 0.66 0
2:177231593:C A337G missense_variant 0.66 0
2:177231593:T A337E missense_variant 0.66 0
2:177234246:T W24* stop_gained 0.65 0
2:177234082:A E79* stop_gained 0.65 0
2:177234007:C Q104E missense_variant 0.64 0
2:177234007:T Q104K missense_variant 0.64 0
2:177231390:C Q405E missense_variant 0.64 0
2:177230972:T G544E missense_variant 0.64 0
2:177230972:G G544A missense_variant 0.64 0
2:177230972:A G544V missense_variant 0.64 0
2:177231390:T Q405K missense_variant 0.64 0
2:177231205:C I466M missense_variant 0.63 0
2:177234080:G E79D missense_variant 0.63 0
2:177234080:A E79D missense_variant 0.63 0
2:177231574:T D343E missense_variant 0.63 0
2:177231574:C D343E missense_variant 0.63 0
2:177264554:C P8R missense_variant 0.63 0
2:177264554:T P8Q missense_variant 0.63 0
2:177264554:A P8L missense_variant 0.63 0
2:177264551:T P9Q missense_variant 0.63 0
2:177264551:A P9L missense_variant 0.63 0
2:177264551:C P9R missense_variant 0.63 0
2:177231556:C N349K missense_variant 0.62 0
2:177231556:T N349K missense_variant 0.62 0
2:177230964:T D547N missense_variant 0.62 0
2:177230964:G D547H missense_variant 0.62 0
2:177230964:A D547Y missense_variant 0.62 0
2:177264565:G L4F missense_variant 0.62 0
2:177264565:A L4F missense_variant 0.62 0
2:177231600:A S335C missense_variant 0.61 0
2:177231229:G E458D missense_variant 0.61 0
2:177231600:C S335G missense_variant 0.61 0
2:177231600:G S335R missense_variant 0.61 0
2:177231229:A E458D missense_variant 0.61 0
2:177231530:G E358A missense_variant 0.61 0
2:177231530:A E358V missense_variant 0.61 0
2:177231530:C E358G missense_variant 0.61 0
2:177231386:C P406R missense_variant 0.61 0
2:177231386:T P406H missense_variant 0.61 0
2:177231386:A P406L missense_variant 0.61 0
2:177234069:T F83Y missense_variant 0.59 0
2:177234069:C F83C missense_variant 0.59 0
2:177234069:G F83S missense_variant 0.59 0
2:177230952:A H551Y missense_variant 0.58 0
2:177230952:C H551D missense_variant 0.58 0
2:177230952:T H551N missense_variant 0.58 0
2:177231416:A P396L missense_variant 0.58 0
2:177234058:C Q87E missense_variant 0.58 0
2:177234058:T Q87K missense_variant 0.58 0
2:177231416:T P396Q missense_variant 0.58 0
2:177231416:C P396R missense_variant 0.58 0
2:177230790:G N605H missense_variant 0.57 0
2:177230790:C N605D missense_variant 0.57 0
2:177230790:A N605Y missense_variant 0.57 0
2:177234054:C P88R missense_variant 0.57 0
2:177234054:A P88L missense_variant 0.57 0
2:177234054:T P88Q missense_variant 0.57 0
2:177231998:T I202N missense_variant 0.57 0
2:177234121:C Q66E missense_variant 0.57 0
2:177234121:T Q66K missense_variant 0.57 0
2:177231632:C L324R missense_variant 0.57 0
2:177231632:G L324P missense_variant 0.57 0
2:177231998:G I202T missense_variant 0.57 0
2:177231998:C I202S missense_variant 0.57 0
2:177231632:T L324H missense_variant 0.57 0
2:177231737:G F289S missense_variant 0.57 0
2:177231737:T F289Y missense_variant 0.57 0
2:177231737:C F289C missense_variant 0.57 0
2:177230897:T R569H missense_variant 0.57 0
2:177232531:A E152V missense_variant 0.57 0
2:177232531:C E152G missense_variant 0.57 0
2:177232531:G E152A missense_variant 0.57 0
2:177230897:A R569L missense_variant 0.57 0
2:177230897:G R569P missense_variant 0.57 0
2:177231014:C D530G missense_variant 0.55 0
2:177231014:A D530V missense_variant 0.55 0
2:177231014:G D530A missense_variant 0.55 0
2:177230930:A S558I missense_variant 0.54 0
2:177230930:G S558T missense_variant 0.54 0
2:177230930:T S558N missense_variant 0.54 0
2:177231800:T V268E missense_variant 0.54 0
2:177231800:G V268A missense_variant 0.54 0
2:177231800:C V268G missense_variant 0.54 0
2:177230806:G K599N missense_variant 0.54 0
2:177230806:A K599N missense_variant 0.54 0
2:177231963:T P214T missense_variant 0.54 0
2:177231963:A P214S missense_variant 0.54 0
2:177231963:C P214A missense_variant 0.54 0
2:177230975:A K543I missense_variant 0.54 0
2:177230975:C K543R missense_variant 0.54 0
2:177230975:G K543T missense_variant 0.54 0
2:177233252:T E134K missense_variant 0.54 0
2:177233252:G E134Q missense_variant 0.54 0
2:177231939:T E222K missense_variant 0.53 0
2:177231939:G E222Q missense_variant 0.53 0
2:177233281:C A124G missense_variant 0.53 0
2:177231651:A D318Y missense_variant 0.53 0
2:177231651:T D318N missense_variant 0.53 0
2:177231651:G D318H missense_variant 0.53 0
2:177233281:A A124V missense_variant 0.53 0
2:177233281:T A124E missense_variant 0.53 0
2:177231692:T T304N missense_variant 0.53 0
2:177231692:A T304I missense_variant 0.53 0
2:177231692:C T304S missense_variant 0.53 0
2:177231108:A R499W missense_variant 0.53 0
2:177231108:C R499G missense_variant 0.53 0
2:177234257:C I20M missense_variant 0.53 0
2:177231821:G E261A missense_variant 0.53 0
2:177231821:A E261V missense_variant 0.53 0
2:177231821:C E261G missense_variant 0.53 0
2:177234190:A R43W missense_variant 0.53 0
2:177231333:G N424H missense_variant 0.50 0
2:177231333:A N424Y missense_variant 0.50 0
2:177231333:C N424D missense_variant 0.50 0
2:177231687:C S306G missense_variant 0.50 0
2:177231687:A S306C missense_variant 0.50 0
2:177231687:G S306R missense_variant 0.50 0
2:177231153:A M484L missense_variant 0.50 0
2:177231153:G M484L missense_variant 0.50 0
2:177231153:C M484V missense_variant 0.50 0
2:177230813:T S597N missense_variant 0.50 0
2:177230813:G S597T missense_variant 0.50 0
2:177230813:A S597I missense_variant 0.50 0
2:177231602:A E334V missense_variant 0.50 0
2:177231602:G E334A missense_variant 0.50 0
2:177231602:C E334G missense_variant 0.50 0
2:177232460:G D176H missense_variant 0.50 0
2:177232460:A D176Y missense_variant 0.50 0
2:177232460:T D176N missense_variant 0.50 0
2:177231266:C H446R missense_variant 0.50 0
2:177231266:A H446L missense_variant 0.50 0
2:177231266:G H446P missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(UCEC) Endometrial cancer UCEC 0.53 0.11