Top
VHL RCCC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
3:10142110:A W88* stop_gained 1.00 4
3:10149886:C L188P missense_variant 1.00 4
3:10146516:T H115Y missense_variant 0.98 4
3:10146516:A H115N missense_variant 0.98 4
3:10142068:A V74D missense_variant 0.92 4
3:10142041:A S65* stop_gained 1.00 3
3:10149879:T E186* stop_gained 1.00 3
3:10149840:T E173* stop_gained 1.00 3
3:10146606:T Q145* stop_gained 1.00 3
3:10149856:C L178P missense_variant 1.00 3
3:10149829:C L169P missense_variant 1.00 3
3:10149796:G L158R missense_variant 1.00 3
3:10142113:A L89H missense_variant 0.99 3
3:10146625:G I151S missense_variant 0.99 3
3:10146556:A L128H missense_variant 0.98 3
3:10142179:A S111N missense_variant 0.94 3
3:10146534:T D121Y missense_variant 0.94 3
3:10149795:G L158V missense_variant 0.92 3
3:10149808:A C162Y missense_variant 0.89 3
3:10149798:T K159* stop_gained 1.00 2
3:10149888:T E189* stop_gained 1.00 2
3:10149852:T R177* stop_gained 1.00 2
3:10149804:T R161* stop_gained 1.00 2
3:10149813:T Q164* stop_gained 1.00 2
3:10149874:C L184P missense_variant 1.00 2
3:10146526:C L118P missense_variant 1.00 2
3:10149796:A L158Q missense_variant 1.00 2
3:10142109:A W88R missense_variant 0.99 2
3:10146625:C I151T missense_variant 0.99 2
3:10142041:T S65L missense_variant 0.99 2
3:10142104:T P86L missense_variant 0.99 2
3:10142079:G N78D missense_variant 0.98 2
3:10142080:G N78S missense_variant 0.98 2
3:10142050:A S68* stop_gained 0.98 2
3:10142078:A C77* stop_gained 0.95 2
3:10146561:T V130F missense_variant 0.94 2
3:10142111:A W88* stop_gained 1.00 1
3:10149848:A Y175* stop_gained 1.00 1
3:10142183:A Y112* stop_gained 1.00 1
3:10146524:A W117* stop_gained 1.00 1
3:10146523:A W117* stop_gained 1.00 1
3:10142127:T E94* stop_gained 1.00 1
3:10149801:T E160* stop_gained 1.00 1
3:10146603:T G144* stop_gained 1.00 1
3:10146579:G F136V missense_variant 1.00 1
3:10142064:T Q73* stop_gained 1.00 1
3:10142184:T R113* stop_gained 1.00 1
3:10142133:T Q96* stop_gained 1.00 1
3:10149817:A V165D missense_variant 1.00 1
3:10149856:G L178R missense_variant 1.00 1
3:10149925:G L201R missense_variant 1.00 1
3:10149886:G L188R missense_variant 1.00 1
3:10149811:A L163H missense_variant 1.00 1
3:10149796:C L158P missense_variant 1.00 1
3:10149909:T K196* stop_gained 1.00 1
3:10146631:C L153P missense_variant 0.99 1
3:10142113:C L89P missense_variant 0.99 1
3:10146625:A I151N missense_variant 0.99 1
3:10142041:G S65W missense_variant 0.99 1
3:10142103:A P86T missense_variant 0.99 1
3:10149878:G Y185* stop_gained 0.99 1
3:10142116:T N90I missense_variant 0.99 1
3:10146514:C G114A missense_variant 0.98 1
3:10142080:T N78I missense_variant 0.98 1
3:10142141:A Y98* stop_gained 0.98 1
3:10142110:T W88L missense_variant 0.98 1
3:10142092:C R82P missense_variant 0.97 1
3:10149906:T Q195* stop_gained 0.97 1
3:10149791:A Y156* stop_gained 0.97 1
3:10146564:T N131Y missense_variant 0.95 1
3:10146561:C V130L missense_variant 0.94 1
3:10142167:C R107P missense_variant 0.94 1
3:10146624:T I151F missense_variant 0.93 1
3:10146566:G N131K missense_variant 0.93 1
3:10146566:A N131K missense_variant 0.93 1
3:10146562:A V130D missense_variant 0.92 1
3:10142068:G V74G missense_variant 0.92 1
3:10149807:C C162R missense_variant 0.90 1
3:10142149:C L101P missense_variant 0.89 1
3:10149844:T N174I missense_variant 0.89 1
3:10146636:C V155L missense_variant 0.88 1
3:10149805:C R161P missense_variant 0.87 1
3:10149831:A V170I missense_variant 0.87 1
3:10142173:A I109N missense_variant 0.85 1
3:10142040:A S65T missense_variant 0.84 1
3:10146524:C W117C missense_variant 0.82 1
3:10149898:A P192Q missense_variant 0.78 1
3:10146520:A L116H missense_variant 0.77 1
3:10142086:A S80N missense_variant 0.68 1
3:10146550:T D126V missense_variant 0.67 1
3:10142176:C H110P missense_variant 0.67 1
3:10146570:C T133P missense_variant 0.59 1
3:10146570:T T133S missense_variant 0.59 1
3:10142031:A V62M missense_variant 0.51 1
3:10146621:T N150Y missense_variant 0.50 1
3:10146577:A L135* stop_gained 1.00 0
3:10146577:G L135* stop_gained 1.00 0
3:10149848:G Y175* stop_gained 1.00 0
3:10149871:A S183* stop_gained 1.00 0
3:10142183:G Y112* stop_gained 1.00 0
3:10149809:A C162* stop_gained 1.00 0
3:10149948:T Q209* stop_gained 1.00 0
3:10146573:T E134* stop_gained 1.00 0
3:10142055:T E70* stop_gained 1.00 0
3:10149874:A L184H missense_variant 1.00 0
3:10149874:G L184R missense_variant 1.00 0
3:10146531:T R120* stop_gained 1.00 0
3:10146526:G L118R missense_variant 1.00 0
3:10146522:C W117R missense_variant 1.00 0
3:10146522:A W117R missense_variant 1.00 0
3:10146526:A L118H missense_variant 1.00 0
3:10146577:C L135S missense_variant 1.00 0
3:10146522:G W117G missense_variant 1.00 0
3:10149846:C Y175H missense_variant 1.00 0
3:10149846:G Y175D missense_variant 1.00 0
3:10149846:A Y175N missense_variant 1.00 0
3:10149918:T E199* stop_gained 1.00 0
3:10146579:A F136I missense_variant 1.00 0
3:10146579:C F136L missense_variant 1.00 0
3:10149933:T E204* stop_gained 1.00 0
3:10149820:G V166G missense_variant 1.00 0
3:10149820:C V166A missense_variant 1.00 0
3:10149820:A V166D missense_variant 1.00 0
3:10149811:C L163P missense_variant 1.00 0
3:10149832:G V170G missense_variant 1.00 0
3:10149925:C L201P missense_variant 1.00 0
3:10149925:A L201Q missense_variant 1.00 0
3:10149916:G L198R missense_variant 1.00 0
3:10149829:G L169R missense_variant 1.00 0
3:10149856:A L178Q missense_variant 1.00 0
3:10149862:A I180N missense_variant 1.00 0
3:10149862:C I180T missense_variant 1.00 0
3:10149862:G I180S missense_variant 1.00 0
3:10149886:A L188Q missense_variant 1.00 0
3:10149904:A V194E missense_variant 1.00 0
3:10149904:C V194A missense_variant 1.00 0
3:10149904:G V194G missense_variant 1.00 0
3:10149811:G L163R missense_variant 1.00 0
3:10149916:C L198P missense_variant 1.00 0
3:10149916:A L198Q missense_variant 1.00 0
3:10149817:G V165G missense_variant 1.00 0
3:10149817:C V165A missense_variant 1.00 0
3:10149787:A V155E missense_variant 1.00 0
3:10149787:C V155A missense_variant 1.00 0
3:10149787:G V155G missense_variant 1.00 0
3:10149832:A V170D missense_variant 1.00 0
3:10149832:C V170A missense_variant 1.00 0
3:10149829:A L169Q missense_variant 1.00 0
3:10149834:T K171* stop_gained 1.00 0
3:10146567:T Q132* stop_gained 1.00 0
3:10141863:T E6* stop_gained 0.99 0
3:10146631:A L153Q missense_variant 0.99 0
3:10146631:G L153R missense_variant 0.99 0
3:10142118:A F91I missense_variant 0.99 0
3:10142109:C W88R missense_variant 0.99 0
3:10142113:G L89R missense_variant 0.99 0
3:10142119:G F91C missense_variant 0.99 0
3:10142109:G W88G missense_variant 0.99 0
3:10142118:C F91L missense_variant 0.99 0
3:10142118:G F91V missense_variant 0.99 0
3:10142119:A F91Y missense_variant 0.99 0
3:10142119:C F91S missense_variant 0.99 0
3:10142010:T E55* stop_gained 0.99 0
3:10141971:T E42* stop_gained 0.99 0
3:10141986:T E47* stop_gained 0.99 0
3:10142107:A V87E missense_variant 0.99 0
3:10142107:C V87A missense_variant 0.99 0
3:10142107:G V87G missense_variant 0.99 0
3:10142091:G R82G missense_variant 0.99 0
3:10142091:A R82S missense_variant 0.99 0
3:10142091:T R82C missense_variant 0.99 0
3:10142104:G P86R missense_variant 0.99 0
3:10142104:A P86H missense_variant 0.99 0
3:10142103:T P86S missense_variant 0.99 0
3:10142103:G P86A missense_variant 0.99 0
3:10149878:A Y185* stop_gained 0.99 0
3:10149930:T Q203* stop_gained 0.99 0
3:10142085:G S80G missense_variant 0.99 0
3:10142085:T S80C missense_variant 0.99 0
3:10142085:C S80R missense_variant 0.99 0
3:10141881:T E12* stop_gained 0.99 0
3:10142116:G N90S missense_variant 0.99 0
3:10142116:C N90T missense_variant 0.99 0
3:10146514:T G114V missense_variant 0.98 0
3:10146514:A G114D missense_variant 0.98 0
3:10142080:C N78T missense_variant 0.98 0
3:10142079:C N78H missense_variant 0.98 0
3:10142079:T N78Y missense_variant 0.98 0
3:10146544:A T124K missense_variant 0.98 0
3:10146516:G H115D missense_variant 0.98 0
3:10146544:G T124R missense_variant 0.98 0
3:10146544:T T124I missense_variant 0.98 0
3:10141968:T E41* stop_gained 0.98 0
3:10142141:G Y98* stop_gained 0.98 0
3:10141893:T E16* stop_gained 0.98 0
3:10142111:T W88C missense_variant 0.98 0
3:10142110:C W88S missense_variant 0.98 0
3:10142124:T G93C missense_variant 0.98 0
3:10142124:C G93R missense_variant 0.98 0
3:10142124:A G93S missense_variant 0.98 0
3:10142111:C W88C missense_variant 0.98 0
3:10142158:T G104V missense_variant 0.98 0
3:10142163:A G106S missense_variant 0.98 0
3:10146528:G F119V missense_variant 0.98 0
3:10142164:A G106D missense_variant 0.98 0
3:10142158:A G104D missense_variant 0.98 0
3:10142158:C G104A missense_variant 0.98 0
3:10146556:C L128P missense_variant 0.98 0
3:10146556:G L128R missense_variant 0.98 0
3:10142163:C G106R missense_variant 0.98 0
3:10142163:T G106C missense_variant 0.98 0
3:10142164:C G106A missense_variant 0.98 0
3:10146528:C F119L missense_variant 0.98 0
3:10146529:G F119C missense_variant 0.98 0
3:10146529:C F119S missense_variant 0.98 0
3:10142164:T G106V missense_variant 0.98 0
3:10146528:A F119I missense_variant 0.98 0
3:10146529:A F119Y missense_variant 0.98 0
3:10141871:A W8* stop_gained 0.97 0
3:10142092:T R82L missense_variant 0.97 0
3:10142092:A R82H missense_variant 0.97 0
3:10149791:G Y156* stop_gained 0.97 0
3:10141926:T E27* stop_gained 0.97 0
3:10141923:T E26* stop_gained 0.97 0
3:10149957:T G212* stop_gained 0.96 0
3:10142053:A R69H missense_variant 0.96 0
3:10142097:A V84M missense_variant 0.96 0
3:10142097:C V84L missense_variant 0.96 0
3:10142067:A V74I missense_variant 0.96 0
3:10142053:C R69P missense_variant 0.96 0
3:10142097:T V84L missense_variant 0.96 0
3:10142067:T V74F missense_variant 0.96 0
3:10142053:T R69L missense_variant 0.96 0
3:10142067:C V74L missense_variant 0.96 0
3:10141875:T E10* stop_gained 0.96 0
3:10146564:G N131D missense_variant 0.95 0
3:10146574:T E134V missense_variant 0.95 0
3:10146574:G E134G missense_variant 0.95 0
3:10146517:T H115L missense_variant 0.95 0
3:10146517:G H115R missense_variant 0.95 0
3:10146574:C E134A missense_variant 0.95 0
3:10146565:T N131I missense_variant 0.95 0
3:10146565:G N131S missense_variant 0.95 0
3:10146565:C N131T missense_variant 0.95 0
3:10146517:C H115P missense_variant 0.95 0
3:10146564:C N131H missense_variant 0.95 0
3:10149798:C K159Q missense_variant 0.95 0
3:10149798:G K159E missense_variant 0.95 0
3:10141945:A S33* stop_gained 0.95 0
3:10141941:T E32* stop_gained 0.95 0
3:10141938:T E31* stop_gained 0.95 0
3:10141870:A W8* stop_gained 0.95 0
3:10142179:T S111I missense_variant 0.94 0
3:10142179:C S111T missense_variant 0.94 0
3:10141983:T E46* stop_gained 0.94 0
3:10146537:C A122P missense_variant 0.94 0
3:10146537:T A122S missense_variant 0.94 0
3:10146532:T R120I missense_variant 0.94 0
3:10146534:A D121N missense_variant 0.94 0
3:10146549:T D126Y missense_variant 0.94 0
3:10146532:A R120K missense_variant 0.94 0
3:10146532:C R120T missense_variant 0.94 0
3:10146561:A V130I missense_variant 0.94 0
3:10146549:A D126N missense_variant 0.94 0
3:10146549:C D126H missense_variant 0.94 0
3:10146534:C D121H missense_variant 0.94 0
3:10146537:A A122T missense_variant 0.94 0
3:10142167:T R107L missense_variant 0.94 0
3:10142167:A R107H missense_variant 0.94 0
3:10146624:G I151V missense_variant 0.93 0
3:10146624:C I151L missense_variant 0.93 0
3:10146530:G F119L missense_variant 0.93 0
3:10146530:A F119L missense_variant 0.93 0
3:10141908:T E21* stop_gained 0.93 0
3:10142178:G S111G missense_variant 0.93 0
3:10142178:C S111R missense_variant 0.93 0
3:10142178:T S111C missense_variant 0.93 0
3:10142187:A G114S missense_variant 0.92 0
3:10142187:C G114R missense_variant 0.92 0
3:10142187:T G114C missense_variant 0.92 0
3:10146562:C V130A missense_variant 0.92 0
3:10146562:G V130G missense_variant 0.92 0
3:10142068:C V74A missense_variant 0.92 0
3:10149795:A L158M missense_variant 0.92 0
3:10149871:T S183L missense_variant 0.92 0
3:10149871:G S183W missense_variant 0.92 0
3:10142181:A Y112N missense_variant 0.91 0
3:10142181:C Y112H missense_variant 0.91 0
3:10142181:G Y112D missense_variant 0.91 0
3:10142157:C G104R missense_variant 0.91 0
3:10142157:A G104S missense_variant 0.91 0
3:10142157:T G104C missense_variant 0.91 0
3:10146580:C F136S missense_variant 0.91 0
3:10146580:G F136C missense_variant 0.91 0
3:10146580:A F136Y missense_variant 0.91 0
3:10141911:T E22* stop_gained 0.91 0
3:10146589:A S139Y missense_variant 0.91 0
3:10146589:G S139C missense_variant 0.91 0
3:10146589:T S139F missense_variant 0.91 0
3:10146586:A P138Q missense_variant 0.90 0
3:10146586:G P138R missense_variant 0.90 0
3:10146586:T P138L missense_variant 0.90 0
3:10142046:C N67H missense_variant 0.90 0
3:10142047:C N67T missense_variant 0.90 0
3:10142047:G N67S missense_variant 0.90 0
3:10142047:T N67I missense_variant 0.90 0
3:10142046:T N67Y missense_variant 0.90 0
3:10142046:G N67D missense_variant 0.90 0
3:10149807:G C162G missense_variant 0.90 0
3:10149807:A C162S missense_variant 0.90 0
3:10142149:A L101Q missense_variant 0.89 0
3:10142149:G L101R missense_variant 0.89 0
3:10149922:A R200Q missense_variant 0.89 0
3:10149922:T R200L missense_variant 0.89 0
3:10149922:C R200P missense_variant 0.89 0
3:10142139:G Y98D missense_variant 0.89 0
3:10142139:A Y98N missense_variant 0.89 0
3:10142139:C Y98H missense_variant 0.89 0
3:10149910:T K196I missense_variant 0.89 0
3:10149910:C K196T missense_variant 0.89 0
3:10149910:G K196R missense_variant 0.89 0
3:10142038:T R64L missense_variant 0.89 0
3:10142038:A R64H missense_variant 0.89 0
3:10142038:C R64P missense_variant 0.89 0
3:10146538:A A122E missense_variant 0.89 0
3:10146538:T A122V missense_variant 0.89 0
3:10146538:G A122G missense_variant 0.89 0
3:10149808:T C162F missense_variant 0.89 0
3:10149808:C C162S missense_variant 0.89 0
3:10149892:T D190V missense_variant 0.89 0
3:10149802:C E160A missense_variant 0.89 0
3:10149802:G E160G missense_variant 0.89 0
3:10149802:T E160V missense_variant 0.89 0
3:10149814:C Q164P missense_variant 0.89 0
3:10149814:G Q164R missense_variant 0.89 0
3:10149814:T Q164L missense_variant 0.89 0
3:10149844:C N174T missense_variant 0.89 0
3:10149844:G N174S missense_variant 0.89 0
3:10149859:C D179A missense_variant 0.89 0
3:10149859:G D179G missense_variant 0.89 0
3:10149859:T D179V missense_variant 0.89 0
3:10149883:C D187A missense_variant 0.89 0
3:10149883:G D187G missense_variant 0.89 0
3:10149883:T D187V missense_variant 0.89 0
3:10149889:C E189A missense_variant 0.89 0
3:10149889:G E189G missense_variant 0.89 0
3:10149889:T E189V missense_variant 0.89 0
3:10149892:C D190A missense_variant 0.89 0
3:10149892:G D190G missense_variant 0.89 0
3:10149913:C D197A missense_variant 0.89 0
3:10149913:G D197G missense_variant 0.89 0
3:10149913:T D197V missense_variant 0.89 0
3:10149799:T K159I missense_variant 0.89 0
3:10149799:C K159T missense_variant 0.89 0
3:10149799:G K159R missense_variant 0.89 0
3:10146603:C G144R missense_variant 0.88 0
3:10146603:A G144R missense_variant 0.88 0
3:10141998:T E51* stop_gained 0.88 0
3:10142182:G Y112C missense_variant 0.88 0
3:10142182:C Y112S missense_variant 0.88 0
3:10142182:T Y112F missense_variant 0.88 0
3:10146636:T V155L missense_variant 0.88 0
3:10146636:A V155M missense_variant 0.88 0
3:10149810:G L163V missense_variant 0.88 0
3:10149810:T L163F missense_variant 0.88 0
3:10149810:A L163I missense_variant 0.88 0
3:10149876:A Y185N missense_variant 0.88 0
3:10149876:G Y185D missense_variant 0.88 0
3:10149876:C Y185H missense_variant 0.88 0
3:10142172:C I109L missense_variant 0.88 0
3:10142172:T I109F missense_variant 0.88 0
3:10142172:G I109V missense_variant 0.88 0
3:10142140:C Y98S missense_variant 0.88 0
3:10142140:G Y98C missense_variant 0.88 0
3:10142140:T Y98F missense_variant 0.88 0
3:10141896:T E17* stop_gained 0.87 0
3:10149879:A E186K missense_variant 0.87 0
3:10149850:T R176M missense_variant 0.87 0
3:10149858:A D179N missense_variant 0.87 0
3:10149888:A E189K missense_variant 0.87 0
3:10149912:A D197N missense_variant 0.87 0
3:10149912:C D197H missense_variant 0.87 0
3:10149912:T D197Y missense_variant 0.87 0
3:10149858:C D179H missense_variant 0.87 0
3:10149805:A R161Q missense_variant 0.87 0
3:10149831:T V170F missense_variant 0.87 0
3:10149805:T R161L missense_variant 0.87 0
3:10149850:C R176T missense_variant 0.87 0
3:10149831:C V170L missense_variant 0.87 0
3:10149858:T D179Y missense_variant 0.87 0
3:10149864:A V181I missense_variant 0.87 0
3:10149864:C V181L missense_variant 0.87 0
3:10149823:T R167L missense_variant 0.87 0
3:10149823:C R167P missense_variant 0.87 0
3:10149823:A R167Q missense_variant 0.87 0
3:10149864:T V181F missense_variant 0.87 0
3:10149879:C E186Q missense_variant 0.87 0
3:10149888:C E189Q missense_variant 0.87 0
3:10149850:A R176K missense_variant 0.87 0
3:10142001:T E52* stop_gained 0.87 0
3:10142004:T E53* stop_gained 0.87 0
3:10146633:G P154A missense_variant 0.87 0
3:10146633:T P154S missense_variant 0.87 0
3:10146633:A P154T missense_variant 0.87 0
3:10146634:T P154L missense_variant 0.87 0
3:10146634:G P154R missense_variant 0.87 0
3:10146634:A P154Q missense_variant 0.87 0
3:10149903:A V194M missense_variant 0.87 0
3:10149885:A L188M missense_variant 0.87 0
3:10149885:G L188V missense_variant 0.87 0
3:10149903:T V194L missense_variant 0.87 0
3:10149903:C V194L missense_variant 0.87 0
3:10149792:G T157A missense_variant 0.87 0
3:10149792:T T157S missense_variant 0.87 0
3:10149792:C T157P missense_variant 0.87 0
3:10149837:T P172S missense_variant 0.85 0
3:10149837:G P172A missense_variant 0.85 0
3:10149837:A P172T missense_variant 0.85 0
3:10142173:G I109S missense_variant 0.85 0
3:10142173:C I109T missense_variant 0.85 0
3:10142035:G L63R missense_variant 0.84 0
3:10142035:C L63P missense_variant 0.84 0
3:10142035:A L63Q missense_variant 0.84 0
3:10142040:C S65P missense_variant 0.84 0
3:10142040:G S65A missense_variant 0.84 0
3:10142125:A G93D missense_variant 0.84 0
3:10142125:T G93V missense_variant 0.84 0
3:10142125:C G93A missense_variant 0.84 0
3:10146553:A G127E missense_variant 0.84 0
3:10146553:C G127A missense_variant 0.84 0
3:10146553:T G127V missense_variant 0.84 0
3:10146540:T G123W missense_variant 0.82 0
3:10146540:A G123R missense_variant 0.82 0
3:10146540:C G123R missense_variant 0.82 0
3:10146573:C E134Q missense_variant 0.82 0
3:10146573:A E134K missense_variant 0.82 0
3:10146524:T W117C missense_variant 0.82 0
3:10146618:A A149T missense_variant 0.82 0
3:10146618:C A149P missense_variant 0.82 0
3:10146618:T A149S missense_variant 0.82 0
3:10146523:T W117L missense_variant 0.82 0
3:10146523:C W117S missense_variant 0.82 0
3:10149801:C E160Q missense_variant 0.81 0
3:10149882:T D187Y missense_variant 0.81 0
3:10149882:C D187H missense_variant 0.81 0
3:10149882:A D187N missense_variant 0.81 0
3:10149801:A E160K missense_variant 0.81 0
3:10146628:T T152I missense_variant 0.81 0
3:10146628:A T152K missense_variant 0.81 0
3:10146628:G T152R missense_variant 0.81 0
3:10149826:A S168N missense_variant 0.79 0
3:10149826:C S168T missense_variant 0.79 0
3:10149826:T S168I missense_variant 0.79 0
3:10141956:T E37* stop_gained 0.79 0
3:10141953:T E36* stop_gained 0.78 0
3:10149897:G P192A missense_variant 0.78 0
3:10149838:G P172R missense_variant 0.78 0
3:10149813:A Q164K missense_variant 0.78 0
3:10149813:G Q164E missense_variant 0.78 0
3:10149838:A P172H missense_variant 0.78 0
3:10149897:T P192S missense_variant 0.78 0
3:10149897:A P192T missense_variant 0.78 0
3:10149898:T P192L missense_variant 0.78 0
3:10149898:G P192R missense_variant 0.78 0
3:10149838:T P172L missense_variant 0.78 0
3:10141916:A Y23* stop_gained 0.77 0
3:10141916:G Y23* stop_gained 0.77 0
3:10149891:A D190N missense_variant 0.77 0
3:10149891:T D190Y missense_variant 0.77 0
3:10149891:C D190H missense_variant 0.77 0
3:10146520:C L116P missense_variant 0.77 0
3:10146520:G L116R missense_variant 0.77 0
3:10146535:T D121V missense_variant 0.77 0
3:10146535:G D121G missense_variant 0.77 0
3:10146535:C D121A missense_variant 0.77 0
3:10142122:C D92A missense_variant 0.76 0
3:10142122:G D92G missense_variant 0.76 0
3:10142122:T D92V missense_variant 0.76 0
3:10142155:A P103H missense_variant 0.75 0
3:10142155:G P103R missense_variant 0.75 0
3:10142155:T P103L missense_variant 0.75 0
3:10146608:T Q145H missense_variant 0.73 0
3:10146608:C Q145H missense_variant 0.73 0
3:10146547:T H125L missense_variant 0.72 0
3:10146547:G H125R missense_variant 0.72 0
3:10146547:C H125P missense_variant 0.72 0
3:10146595:T N141I missense_variant 0.70 0
3:10146595:C N141T missense_variant 0.70 0
3:10146595:G N141S missense_variant 0.70 0
3:10149816:A V165I missense_variant 0.69 0
3:10149816:T V165F missense_variant 0.69 0
3:10149816:C V165L missense_variant 0.69 0
3:10149840:C E173Q missense_variant 0.69 0
3:10149840:A E173K missense_variant 0.69 0
3:10146601:C D143A missense_variant 0.69 0
3:10146601:G D143G missense_variant 0.69 0
3:10146601:T D143V missense_variant 0.69 0
3:10149852:G R177G missense_variant 0.68 0
3:10142086:T S80I missense_variant 0.68 0
3:10142086:C S80T missense_variant 0.68 0
3:10149789:G Y156D missense_variant 0.67 0
3:10149789:A Y156N missense_variant 0.67 0
3:10149789:C Y156H missense_variant 0.67 0
3:10146550:G D126G missense_variant 0.67 0
3:10146550:C D126A missense_variant 0.67 0
3:10142176:G H110R missense_variant 0.67 0
3:10142176:T H110L missense_variant 0.67 0
3:10146626:G I151M missense_variant 0.65 0
3:10146568:T Q132L missense_variant 0.65 0
3:10146568:C Q132P missense_variant 0.65 0
3:10146568:G Q132R missense_variant 0.65 0
3:10146543:T T124S missense_variant 0.64 0
3:10146543:G T124A missense_variant 0.64 0
3:10146543:C T124P missense_variant 0.64 0
3:10146555:T L128F missense_variant 0.64 0
3:10146555:G L128V missense_variant 0.64 0
3:10146555:A L128I missense_variant 0.64 0
3:10146559:G L129R missense_variant 0.63 0
3:10146559:C L129P missense_variant 0.63 0
3:10146559:A L129Q missense_variant 0.63 0
3:10142170:T R108L missense_variant 0.63 0
3:10142170:A R108H missense_variant 0.63 0
3:10142170:C R108P missense_variant 0.63 0
3:10146615:G F148V missense_variant 0.62 0
3:10146615:A F148I missense_variant 0.62 0
3:10146615:C F148L missense_variant 0.62 0
3:10146594:G N141D missense_variant 0.62 0
3:10146594:T N141Y missense_variant 0.62 0
3:10146594:C N141H missense_variant 0.62 0
3:10149877:G Y185C missense_variant 0.61 0
3:10149877:T Y185F missense_variant 0.61 0
3:10149877:C Y185S missense_variant 0.61 0
3:10142065:T Q73L missense_variant 0.61 0
3:10142065:C Q73P missense_variant 0.61 0
3:10142065:G Q73R missense_variant 0.61 0
3:10146583:C V137A missense_variant 0.60 0
3:10146583:G V137G missense_variant 0.60 0
3:10146583:A V137E missense_variant 0.60 0
3:10142071:C I75T missense_variant 0.59 0
3:10142074:G F76C missense_variant 0.59 0
3:10142074:C F76S missense_variant 0.59 0
3:10142074:A F76Y missense_variant 0.59 0
3:10142073:G F76V missense_variant 0.59 0
3:10142073:C F76L missense_variant 0.59 0
3:10142073:A F76I missense_variant 0.59 0
3:10142071:G I75S missense_variant 0.59 0
3:10142071:A I75N missense_variant 0.59 0
3:10146570:G T133A missense_variant 0.59 0
3:10142055:A E70K missense_variant 0.57 0
3:10142055:C E70Q missense_variant 0.57 0
3:10142127:C E94Q missense_variant 0.56 0
3:10142127:A E94K missense_variant 0.56 0
3:10142142:A P99T missense_variant 0.54 0
3:10142142:T P99S missense_variant 0.54 0
3:10142142:G P99A missense_variant 0.54 0
3:10149901:G N193S missense_variant 0.53 0
3:10149901:T N193I missense_variant 0.53 0
3:10149901:C N193T missense_variant 0.53 0
3:10149948:A Q209K missense_variant 0.52 0
3:10149948:G Q209E missense_variant 0.52 0
3:10142031:T V62L missense_variant 0.51 0
3:10142031:C V62L missense_variant 0.51 0
3:10146621:G N150D missense_variant 0.50 0
3:10146621:C N150H missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(RCCC) Renal clear cell carcinoma RCCC 0.51 0.29