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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
NOTCH1 HNSC ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
9:136499244:A R1984* stop_gained 0.99 2
9:136513528:T C739* stop_gained 0.99 2
9:136508290:T W1089* stop_gained 1.00 1
9:136514562:A E719* stop_gained 1.00 1
9:136509860:A E948* stop_gained 1.00 1
9:136502035:T W1813* stop_gained 1.00 1
9:136496364:A Q2459* stop_gained 1.00 1
9:136500566:A Q1974* stop_gained 1.00 1
9:136501796:A Q1864* stop_gained 1.00 1
9:136501853:A Q1845* stop_gained 1.00 1
9:136507308:A Q1214* stop_gained 1.00 1
9:136513081:A Q803* stop_gained 1.00 1
9:136518810:A E294* stop_gained 1.00 1
9:136505548:A E1450* stop_gained 1.00 1
9:136506942:T C1225* stop_gained 1.00 1
9:136518245:A E383* stop_gained 1.00 1
9:136508110:A G1119* stop_gained 1.00 1
9:136523178:T C138* stop_gained 1.00 1
9:136516000:T Y550* stop_gained 1.00 1
9:136505648:T C1416* stop_gained 1.00 1
9:136508016:T S1150* stop_gained 1.00 1
9:136508319:A Q1080* stop_gained 0.99 1
9:136515318:C Y662* stop_gained 0.99 1
9:136518798:A E298* stop_gained 1.00 0
9:136508352:A K1069* stop_gained 1.00 0
9:136502381:A K1759* stop_gained 1.00 0
9:136523722:T W133* stop_gained 1.00 0
9:136504821:A E1624* stop_gained 1.00 0
9:136504818:A E1625* stop_gained 1.00 0
9:136509761:A E981* stop_gained 1.00 0
9:136507401:A E1183* stop_gained 1.00 0
9:136523721:T W133* stop_gained 1.00 0
9:136504824:A E1623* stop_gained 1.00 0
9:136496940:A E2267* stop_gained 1.00 0
9:136498977:T W2034* stop_gained 1.00 0
9:136498978:T W2034* stop_gained 1.00 0
9:136517305:A K508* stop_gained 1.00 0
9:136513479:A E756* stop_gained 1.00 0
9:136496421:A Q2440* stop_gained 1.00 0
9:136496598:A Q2381* stop_gained 1.00 0
9:136515317:A E663* stop_gained 1.00 0
9:136504992:A E1567* stop_gained 1.00 0
9:136506628:A E1305* stop_gained 1.00 0
9:136499160:A E2012* stop_gained 1.00 0
9:136499172:A E2008* stop_gained 1.00 0
9:136505474:T W1474* stop_gained 1.00 0
9:136505475:T W1474* stop_gained 1.00 0
9:136517350:A E493* stop_gained 1.00 0
9:136502071:T S1801* stop_gained 1.00 0
9:136502071:C S1801* stop_gained 1.00 0
9:136501910:A E1826* stop_gained 1.00 0
9:136496430:A E2437* stop_gained 1.00 0
9:136496979:A E2254* stop_gained 1.00 0
9:136515984:A E556* stop_gained 1.00 0
9:136506824:A E1265* stop_gained 1.00 0
9:136496809:T W2310* stop_gained 1.00 0
9:136513043:T C815* stop_gained 1.00 0
9:136513510:T W745* stop_gained 1.00 0
9:136502081:A K1798* stop_gained 1.00 0
9:136502012:A K1821* stop_gained 1.00 0
9:136496085:A E2552* stop_gained 1.00 0
9:136513108:A E794* stop_gained 1.00 0
9:136508291:T W1089* stop_gained 1.00 0
9:136502027:A E1816* stop_gained 1.00 0
9:136505557:A E1447* stop_gained 1.00 0
9:136511156:T W861* stop_gained 1.00 0
9:136516026:A K542* stop_gained 1.00 0
9:136498919:A K2054* stop_gained 1.00 0
9:136498994:A K2029* stop_gained 1.00 0
9:136498934:A K2049* stop_gained 1.00 0
9:136504777:T W1638* stop_gained 1.00 0
9:136496568:A Q2391* stop_gained 1.00 0
9:136505674:A E1408* stop_gained 1.00 0
9:136513473:A E758* stop_gained 1.00 0
9:136496264:T S2492* stop_gained 1.00 0
9:136496327:T S2471* stop_gained 1.00 0
9:136502018:A E1819* stop_gained 1.00 0
9:136517845:A E450* stop_gained 1.00 0
9:136517830:A E455* stop_gained 1.00 0
9:136496727:A Q2338* stop_gained 1.00 0
9:136500800:A E1896* stop_gained 1.00 0
9:136500782:A E1902* stop_gained 1.00 0
9:136500785:A E1901* stop_gained 1.00 0
9:136522868:A E242* stop_gained 1.00 0
9:136544088:A Q26* stop_gained 1.00 0
9:136496493:A Q2416* stop_gained 1.00 0
9:136497432:A E2103* stop_gained 1.00 0
9:136496814:A E2309* stop_gained 1.00 0
9:136508023:A E1148* stop_gained 1.00 0
9:136497249:A K2164* stop_gained 1.00 0
9:136509737:A E989* stop_gained 1.00 0
9:136502336:A K1774* stop_gained 1.00 0
9:136502315:A K1781* stop_gained 1.00 0
9:136506809:A E1270* stop_gained 1.00 0
9:136506962:A E1219* stop_gained 1.00 0
9:136506833:A E1262* stop_gained 1.00 0
9:136513441:T C768* stop_gained 1.00 0
9:136507392:A E1186* stop_gained 1.00 0
9:136508371:T W1062* stop_gained 1.00 0
9:136505660:T Y1412* stop_gained 1.00 0
9:136505660:C Y1412* stop_gained 1.00 0
9:136496828:T L2304* stop_gained 1.00 0
9:136517785:A Q470* stop_gained 1.00 0
9:136517770:A Q475* stop_gained 1.00 0
9:136518142:T S417* stop_gained 1.00 0
9:136509903:T C933* stop_gained 1.00 0
9:136505332:A Q1522* stop_gained 1.00 0
9:136508888:T Y1051* stop_gained 1.00 0
9:136508932:A Q1037* stop_gained 1.00 0
9:136508896:A Q1049* stop_gained 1.00 0
9:136508888:C Y1051* stop_gained 1.00 0
9:136500776:A E1904* stop_gained 1.00 0
9:136500779:A E1903* stop_gained 1.00 0
9:136503269:A Q1694* stop_gained 1.00 0
9:136508065:A Q1134* stop_gained 1.00 0
9:136523051:A E181* stop_gained 1.00 0
9:136513049:T Y813* stop_gained 1.00 0
9:136513049:C Y813* stop_gained 1.00 0
9:136517809:A Q462* stop_gained 1.00 0
9:136507332:A K1206* stop_gained 1.00 0
9:136505413:A Q1495* stop_gained 1.00 0
9:136505408:T C1496* stop_gained 1.00 0
9:136496985:A K2252* stop_gained 1.00 0
9:136496238:A Q2501* stop_gained 1.00 0
9:136517869:A Q442* stop_gained 1.00 0
9:136505426:T C1490* stop_gained 1.00 0
9:136518187:T S402* stop_gained 1.00 0
9:136505374:A Q1508* stop_gained 1.00 0
9:136513511:T W745* stop_gained 1.00 0
9:136518792:A Q300* stop_gained 1.00 0
9:136505091:A Q1534* stop_gained 1.00 0
9:136505860:A E1346* stop_gained 1.00 0
9:136509030:T S1004* stop_gained 1.00 0
9:136518754:T C312* stop_gained 1.00 0
9:136497391:C Y2116* stop_gained 1.00 0
9:136497391:T Y2116* stop_gained 1.00 0
9:136523948:A Q58* stop_gained 1.00 0
9:136511155:A Q862* stop_gained 1.00 0
9:136503290:A Q1687* stop_gained 1.00 0
9:136496589:A Q2384* stop_gained 1.00 0
9:136504698:A E1665* stop_gained 1.00 0
9:136523018:A G192* stop_gained 1.00 0
9:136496361:A E2460* stop_gained 1.00 0
9:136501790:A E1866* stop_gained 1.00 0
9:136518709:T W327* stop_gained 1.00 0
9:136518710:T W327* stop_gained 1.00 0
9:136515696:A E564* stop_gained 1.00 0
9:136496810:T W2310* stop_gained 1.00 0
9:136502353:T W1768* stop_gained 1.00 0
9:136502352:T W1768* stop_gained 1.00 0
9:136502345:A E1771* stop_gained 1.00 0
9:136497129:A E2204* stop_gained 1.00 0
9:136515389:A E639* stop_gained 1.00 0
9:136502303:A E1785* stop_gained 1.00 0
9:136501907:A E1827* stop_gained 1.00 0
9:136501857:T W1843* stop_gained 1.00 0
9:136501858:T W1843* stop_gained 1.00 0
9:136508331:A Q1076* stop_gained 1.00 0
9:136515570:A E606* stop_gained 1.00 0
9:136497225:A E2172* stop_gained 1.00 0
9:136502312:A K1782* stop_gained 1.00 0
9:136497317:T S2141* stop_gained 1.00 0
9:136517851:A R448* stop_gained 1.00 0
9:136497069:A Q2224* stop_gained 1.00 0
9:136502369:A Q1763* stop_gained 1.00 0
9:136497516:A E2075* stop_gained 1.00 0
9:136497528:A E2071* stop_gained 1.00 0
9:136497555:A E2062* stop_gained 1.00 0
9:136497396:A E2115* stop_gained 1.00 0
9:136497558:A E2061* stop_gained 1.00 0
9:136517776:A E473* stop_gained 1.00 0
9:136506761:A Q1286* stop_gained 1.00 0
9:136505436:T W1487* stop_gained 1.00 0
9:136505435:T W1487* stop_gained 1.00 0
9:136505405:T W1497* stop_gained 1.00 0
9:136505406:T W1497* stop_gained 1.00 0
9:136501862:A Q1842* stop_gained 1.00 0
9:136505024:T W1556* stop_gained 1.00 0
9:136505028:A E1555* stop_gained 1.00 0
9:136505034:A E1553* stop_gained 1.00 0
9:136500641:A E1949* stop_gained 1.00 0
9:136500701:A E1929* stop_gained 1.00 0
9:136522946:A E216* stop_gained 1.00 0
9:136505023:T W1556* stop_gained 1.00 0
9:136496139:A E2534* stop_gained 1.00 0
9:136496180:T W2520* stop_gained 1.00 0
9:136496143:T W2532* stop_gained 1.00 0
9:136496144:T W2532* stop_gained 1.00 0
9:136496179:T W2520* stop_gained 1.00 0
9:136518771:A Q307* stop_gained 1.00 0
9:136496820:A Q2307* stop_gained 1.00 0
9:136514676:A E681* stop_gained 1.00 0
9:136510680:A E905* stop_gained 1.00 0
9:136503239:A G1704* stop_gained 1.00 0
9:136503314:A E1679* stop_gained 1.00 0
9:136515483:A G635* stop_gained 1.00 0
9:136522974:T C206* stop_gained 1.00 0
9:136516059:A E531* stop_gained 1.00 0
9:136522910:A Q228* stop_gained 1.00 0
9:136511157:T W861* stop_gained 1.00 0
9:136502318:A K1780* stop_gained 1.00 0
9:136510779:A E872* stop_gained 1.00 0
9:136502273:A K1795* stop_gained 1.00 0
9:136514593:T Y708* stop_gained 1.00 0
9:136514593:C Y708* stop_gained 1.00 0
9:136496223:A E2506* stop_gained 1.00 0
9:136519465:T C281* stop_gained 1.00 0
9:136502034:T W1813* stop_gained 1.00 0
9:136502039:A E1812* stop_gained 1.00 0
9:136511260:A E827* stop_gained 1.00 0
9:136496196:A E2515* stop_gained 1.00 0
9:136496556:A Q2395* stop_gained 1.00 0
9:136497066:A Q2225* stop_gained 1.00 0
9:136496171:T S2523* stop_gained 1.00 0
9:136510803:A Q864* stop_gained 1.00 0
9:136523719:T S134* stop_gained 1.00 0
9:136523719:C S134* stop_gained 1.00 0
9:136496076:A K2555* stop_gained 1.00 0
9:136500653:A K1945* stop_gained 1.00 0
9:136496592:A Q2383* stop_gained 1.00 0
9:136508971:A E1024* stop_gained 1.00 0
9:136497507:A K2078* stop_gained 1.00 0
9:136497198:A K2181* stop_gained 1.00 0
9:136497270:A K2157* stop_gained 1.00 0
9:136497273:A K2156* stop_gained 1.00 0
9:136497210:A K2177* stop_gained 1.00 0
9:136497291:A K2150* stop_gained 1.00 0
9:136496103:A Q2546* stop_gained 1.00 0
9:136522918:T S225* stop_gained 1.00 0
9:136508961:T S1027* stop_gained 1.00 0
9:136508961:C S1027* stop_gained 1.00 0
9:136496301:A Q2480* stop_gained 1.00 0
9:136505052:A Q1547* stop_gained 1.00 0
9:136497304:T Y2145* stop_gained 1.00 0
9:136497304:C Y2145* stop_gained 1.00 0
9:136496523:A Q2406* stop_gained 1.00 0
9:136496471:C S2423* stop_gained 1.00 0
9:136496471:T S2423* stop_gained 1.00 0
9:136497095:T S2215* stop_gained 1.00 0
9:136497107:T S2211* stop_gained 1.00 0
9:136497125:C S2205* stop_gained 1.00 0
9:136497125:T S2205* stop_gained 1.00 0
9:136497146:T S2198* stop_gained 1.00 0
9:136497189:A Q2184* stop_gained 1.00 0
9:136497279:A Q2154* stop_gained 1.00 0
9:136497332:T S2136* stop_gained 1.00 0
9:136497435:A Q2102* stop_gained 1.00 0
9:136498910:A Q2057* stop_gained 1.00 0
9:136496796:A Q2315* stop_gained 1.00 0
9:136496775:A Q2322* stop_gained 1.00 0
9:136496712:A Q2343* stop_gained 1.00 0
9:136500554:A Q1978* stop_gained 1.00 0
9:136496658:A Q2361* stop_gained 1.00 0
9:136500617:A Q1957* stop_gained 1.00 0
9:136500670:C S1939* stop_gained 1.00 0
9:136500670:T S1939* stop_gained 1.00 0
9:136500691:T L1932* stop_gained 1.00 0
9:136500719:A Q1923* stop_gained 1.00 0
9:136500740:A Q1916* stop_gained 1.00 0
9:136501850:A Q1846* stop_gained 1.00 0
9:136501877:A Q1837* stop_gained 1.00 0
9:136496643:A Q2366* stop_gained 1.00 0
9:136496613:A Q2376* stop_gained 1.00 0
9:136502045:A Q1810* stop_gained 1.00 0
9:136513123:A Q789* stop_gained 1.00 0
9:136508872:A Q1057* stop_gained 1.00 0
9:136503226:T S1708* stop_gained 1.00 0
9:136508360:T S1066* stop_gained 1.00 0
9:136503299:A Q1684* stop_gained 1.00 0
9:136496409:A Q2444* stop_gained 1.00 0
9:136518822:A Q290* stop_gained 1.00 0
9:136505312:T C1528* stop_gained 1.00 0
9:136508042:T Y1141* stop_gained 1.00 0
9:136508042:C Y1141* stop_gained 1.00 0
9:136496282:T S2486* stop_gained 1.00 0
9:136508002:A Q1155* stop_gained 1.00 0
9:136496280:A Q2487* stop_gained 1.00 0
9:136496232:A Q2503* stop_gained 1.00 0
9:136507371:A Q1193* stop_gained 1.00 0
9:136507333:T Y1205* stop_gained 1.00 0
9:136507333:C Y1205* stop_gained 1.00 0
9:136496184:A Q2519* stop_gained 1.00 0
9:136505746:A Q1384* stop_gained 1.00 0
9:136517820:T S458* stop_gained 1.00 0
9:136516074:A Q526* stop_gained 1.00 0
9:136496109:A Q2544* stop_gained 1.00 0
9:136497107:C S2211* stop_gained 1.00 0
9:136506773:A Q1282* stop_gained 1.00 0
9:136510740:A Q885* stop_gained 1.00 0
9:136496562:A Q2393* stop_gained 1.00 0
9:136504778:T W1638* stop_gained 1.00 0
9:136496514:A Q2409* stop_gained 1.00 0
9:136505621:T C1425* stop_gained 1.00 0
9:136502360:A Q1766* stop_gained 1.00 0
9:136505369:T C1509* stop_gained 1.00 0
9:136505698:A Q1400* stop_gained 1.00 0
9:136496532:A Q2403* stop_gained 1.00 0
9:136523067:T C175* stop_gained 1.00 0
9:136504944:A E1583* stop_gained 1.00 0
9:136497261:A K2160* stop_gained 1.00 0
9:136497219:A K2174* stop_gained 1.00 0
9:136496339:T S2467* stop_gained 1.00 0
9:136504809:A K1628* stop_gained 1.00 0
9:136497228:A K2171* stop_gained 1.00 0
9:136497195:A K2182* stop_gained 1.00 0
9:136496644:C Y2365* stop_gained 1.00 0
9:136496644:T Y2365* stop_gained 1.00 0
9:136519448:T W287* stop_gained 1.00 0
9:136523117:A E159* stop_gained 1.00 0
9:136517923:A E424* stop_gained 1.00 0
9:136515294:C Y670* stop_gained 1.00 0
9:136515294:T Y670* stop_gained 1.00 0
9:136509872:A E944* stop_gained 1.00 0
9:136509875:A E943* stop_gained 1.00 0
9:136544079:A E29* stop_gained 1.00 0
9:136517911:A K428* stop_gained 1.00 0
9:136506858:T C1253* stop_gained 1.00 0
9:136513408:T C779* stop_gained 1.00 0
9:136506908:A K1237* stop_gained 1.00 0
9:136517792:T C467* stop_gained 1.00 0
9:136523174:A Q140* stop_gained 1.00 0
9:136505082:A K1537* stop_gained 1.00 0
9:136505807:T C1363* stop_gained 1.00 0
9:136496583:A Q2386* stop_gained 1.00 0
9:136514571:A E716* stop_gained 1.00 0
9:136522911:T C227* stop_gained 1.00 0
9:136523094:T C166* stop_gained 1.00 0
9:136497319:T C2140* stop_gained 1.00 0
9:136496526:A Q2405* stop_gained 1.00 0
9:136504908:A E1595* stop_gained 1.00 0
9:136510708:T C895* stop_gained 1.00 0
9:136523106:C Y162* stop_gained 1.00 0
9:136523106:T Y162* stop_gained 1.00 0
9:136519545:A E255* stop_gained 1.00 0
9:136513534:C Y737* stop_gained 1.00 0
9:136513534:T Y737* stop_gained 1.00 0
9:136519554:A Q252* stop_gained 1.00 0
9:136505752:A E1382* stop_gained 1.00 0
9:136502486:A E1724* stop_gained 1.00 0
9:136508990:C Y1017* stop_gained 1.00 0
9:136508990:T Y1017* stop_gained 1.00 0
9:136500816:T C1890* stop_gained 1.00 0
9:136544034:A E44* stop_gained 1.00 0
9:136505404:A K1498* stop_gained 1.00 0
9:136505422:A Q1492* stop_gained 1.00 0
9:136502327:A E1777* stop_gained 1.00 0
9:136508332:T W1075* stop_gained 1.00 0
9:136506538:A K1335* stop_gained 1.00 0
9:136511224:A R839* stop_gained 1.00 0
9:136503278:A Q1691* stop_gained 1.00 0
9:136511197:A E848* stop_gained 1.00 0
9:136508235:A Q1108* stop_gained 1.00 0
9:136517884:A E437* stop_gained 1.00 0
9:136508003:T C1154* stop_gained 1.00 0
9:136505641:A K1419* stop_gained 1.00 0
9:136505747:T C1383* stop_gained 1.00 0
9:136517380:A E483* stop_gained 1.00 0
9:136496559:A Q2394* stop_gained 1.00 0
9:136517878:A Q439* stop_gained 1.00 0
9:136506737:A E1294* stop_gained 1.00 0
9:136505780:T C1372* stop_gained 1.00 0
9:136523025:T C189* stop_gained 1.00 0
9:136522926:T C222* stop_gained 1.00 0
9:136503194:A E1719* stop_gained 1.00 0
9:136519459:T C283* stop_gained 1.00 0
9:136522893:T C233* stop_gained 1.00 0
9:136508302:T C1085* stop_gained 1.00 0
9:136509822:T C960* stop_gained 1.00 0
9:136518149:A E415* stop_gained 1.00 0
9:136513048:A K814* stop_gained 1.00 0
9:136517861:C Y444* stop_gained 1.00 0
9:136505539:A E1453* stop_gained 1.00 0
9:136517861:T Y444* stop_gained 1.00 0
9:136508372:T W1062* stop_gained 1.00 0
9:136517285:T C514* stop_gained 1.00 0
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9:136514557:T C720* stop_gained 0.99 0
9:136518673:T C339* stop_gained 0.99 0
9:136506575:T C1322* stop_gained 0.99 0
9:136505381:T C1505* stop_gained 0.99 0
9:136518721:T C323* stop_gained 0.99 0
9:136518727:T C321* stop_gained 0.99 0
9:136506592:A K1317* stop_gained 0.99 0
9:136508308:T C1083* stop_gained 0.99 0
9:136505095:T Y1532* stop_gained 0.99 0
9:136513495:T C750* stop_gained 0.99 0
9:136505095:C Y1532* stop_gained 0.99 0
9:136513474:T C757* stop_gained 0.99 0
9:136513459:T C762* stop_gained 0.99 0
9:136505056:T C1545* stop_gained 0.99 0
9:136505029:T C1554* stop_gained 0.99 0
9:136505008:T C1561* stop_gained 0.99 0
9:136508368:T C1063* stop_gained 0.99 0
9:136504831:T Y1620* stop_gained 0.99 0
9:136504831:C Y1620* stop_gained 0.99 0
9:136517765:T C476* stop_gained 0.99 0
9:136519492:T C272* stop_gained 0.99 0
9:136515354:T C650* stop_gained 0.99 0
9:136517366:T C487* stop_gained 0.99 0
9:136519546:T C254* stop_gained 0.99 0
9:136522857:T C245* stop_gained 0.99 0
9:136506629:T C1304* stop_gained 0.99 0
9:136504719:A E1658* stop_gained 0.99 0
9:136509855:T C949* stop_gained 0.99 0
9:136510795:T C866* stop_gained 0.99 0
9:136509876:T C942* stop_gained 0.99 0
9:136544026:T C46* stop_gained 0.99 0
9:136515676:T C570* stop_gained 0.99 0
9:136515655:T Y577* stop_gained 0.99 0
9:136510774:T C873* stop_gained 0.99 0
9:136515655:C Y577* stop_gained 0.99 0
9:136510681:T C904* stop_gained 0.99 0
9:136506885:T C1244* stop_gained 0.99 0
9:136498899:T R2060R splice_region_variant 0.96 0
9:136498901:G R2060R splice_region_variant 0.95 0
9:136500552:T Q1978Q splice_region_variant 0.91 0
9:136505312:A C1528C splice_region_variant 0.88 0
9:136508870:T Q1057Q splice_region_variant 0.85 0
9:136522851:G P247P splice_region_variant 0.84 0
9:136522851:C P247P splice_region_variant 0.84 0
9:136522851:A P247P splice_region_variant 0.84 0
9:136507955:T K1170K splice_region_variant 0.84 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(HNSC) Head and neck squamous cell carcinoma HNSC 0.20 0.04