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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
MAP2K1 CM ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
15:66436824:T P124S missense_variant 1.00 21
15:66436825:T P124L missense_variant 1.00 7
15:66481793:A E203K missense_variant 0.97 4
15:66435117:T K57N missense_variant 0.89 2
15:66436818:G N122D missense_variant 1.00 1
15:66435103:A F53I missense_variant 0.99 1
15:66435107:C L54P missense_variant 0.98 1
15:66481794:T E203V missense_variant 0.92 1
15:66435113:C Q56P missense_variant 0.92 1
15:66436825:G P124R missense_variant 1.00 0
15:66436824:A P124T missense_variant 1.00 0
15:66436824:G P124A missense_variant 1.00 0
15:66436825:A P124Q missense_variant 1.00 0
15:66436818:T N122Y missense_variant 1.00 0
15:66436818:C N122H missense_variant 1.00 0
15:66436819:T N122I missense_variant 1.00 0
15:66436819:G N122S missense_variant 1.00 0
15:66436819:C N122T missense_variant 1.00 0
15:66436820:A N122K missense_variant 1.00 0
15:66436820:G N122K missense_variant 1.00 0
15:66436839:G F129V missense_variant 0.99 0
15:66436840:G F129C missense_variant 0.99 0
15:66436840:C F129S missense_variant 0.99 0
15:66436840:A F129Y missense_variant 0.99 0
15:66436827:G Y125D missense_variant 0.99 0
15:66436839:C F129L missense_variant 0.99 0
15:66436839:A F129I missense_variant 0.99 0
15:66436834:G V127G missense_variant 0.99 0
15:66436834:C V127A missense_variant 0.99 0
15:66436834:A V127E missense_variant 0.99 0
15:66436831:G I126S missense_variant 0.99 0
15:66436831:C I126T missense_variant 0.99 0
15:66436831:A I126N missense_variant 0.99 0
15:66436821:A S123T missense_variant 0.99 0
15:66436821:C S123P missense_variant 0.99 0
15:66436821:G S123A missense_variant 0.99 0
15:66436827:A Y125N missense_variant 0.99 0
15:66436827:C Y125H missense_variant 0.99 0
15:66435103:C F53L missense_variant 0.99 0
15:66435103:G F53V missense_variant 0.99 0
15:66435104:G F53C missense_variant 0.98 0
15:66435104:C F53S missense_variant 0.98 0
15:66435107:G L54R missense_variant 0.98 0
15:66435107:A L54H missense_variant 0.98 0
15:66435104:A F53Y missense_variant 0.98 0
15:66436822:A S123Y missense_variant 0.97 0
15:66436822:T S123F missense_variant 0.97 0
15:66436822:G S123C missense_variant 0.97 0
15:66481793:C E203Q missense_variant 0.97 0
15:66435112:G Q56E missense_variant 0.96 0
15:66435110:G T55S missense_variant 0.96 0
15:66435110:T T55I missense_variant 0.96 0
15:66435112:A Q56K missense_variant 0.96 0
15:66435106:A L54I missense_variant 0.96 0
15:66435106:G L54V missense_variant 0.96 0
15:66435110:A T55N missense_variant 0.96 0
15:66435106:T L54F missense_variant 0.96 0
15:66435116:C K57T missense_variant 0.95 0
15:66435116:G K57R missense_variant 0.95 0
15:66435115:C K57Q missense_variant 0.95 0
15:66435115:G K57E missense_variant 0.95 0
15:66435116:T K57M missense_variant 0.95 0
15:66436828:C Y125S missense_variant 0.94 0
15:66436828:G Y125C missense_variant 0.94 0
15:66436828:T Y125F missense_variant 0.94 0
15:66436830:C I126L missense_variant 0.94 0
15:66436830:G I126V missense_variant 0.94 0
15:66436830:T I126F missense_variant 0.94 0
15:66435114:T Q56H missense_variant 0.93 0
15:66435114:C Q56H missense_variant 0.93 0
15:66481794:G E203G missense_variant 0.92 0
15:66481794:C E203A missense_variant 0.92 0
15:66435113:T Q56L missense_variant 0.92 0
15:66435109:C T55P missense_variant 0.92 0
15:66435109:G T55A missense_variant 0.92 0
15:66435109:T T55S missense_variant 0.92 0
15:66435113:G Q56R missense_variant 0.92 0
15:66436833:C V127L missense_variant 0.92 0
15:66436837:T G128V missense_variant 0.92 0
15:66436833:A V127M missense_variant 0.92 0
15:66436833:T V127L missense_variant 0.92 0
15:66436836:A G128S missense_variant 0.92 0
15:66436836:C G128R missense_variant 0.92 0
15:66436836:T G128C missense_variant 0.92 0
15:66436837:A G128D missense_variant 0.92 0
15:66436837:C G128A missense_variant 0.92 0
15:66481793:T E203* stop_gained 0.91 0
15:66435117:C K57N missense_variant 0.89 0
15:66436841:G F129L missense_variant 0.88 0
15:66436841:A F129L missense_variant 0.88 0
15:66436832:G I126M missense_variant 0.88 0
15:66435115:T K57* stop_gained 0.79 0
15:66435105:A F53L missense_variant 0.79 0
15:66435105:G F53L missense_variant 0.79 0
15:66435112:T Q56* stop_gained 0.78 0
15:66435076:C E44Q missense_variant 0.77 0
15:66435076:A E44K missense_variant 0.77 0
15:66436829:G Y125* stop_gained 0.59 0
15:66436829:A Y125* stop_gained 0.59 0
15:66481795:T E203D missense_variant 0.51 0
15:66481795:C E203D missense_variant 0.51 0
15:66436814:T E120D missense_variant 0.50 0
15:66436814:C E120D missense_variant 0.50 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(CM) Cutaneous melanoma of the skin CM 0.48 0.19