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Note: You're navigating the results of models obtained with the previous release of IntOGen (2020). A new boostDM version corresponding to the current IntOGen release will be available soon.
TP53 BRCA ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
17:7675088:T R175H missense_variant 1.00 45
17:7673802:T R273H missense_variant 1.00 32
17:7674894:A R213* stop_gained 1.00 23
17:7674945:A R196* stop_gained 1.00 22
17:7674220:T R248Q missense_variant 1.00 21
17:7674953:C H193R missense_variant 1.00 17
17:7670685:A R342* stop_gained 1.00 16
17:7674221:A R248W missense_variant 1.00 16
17:7673803:A R273C missense_variant 1.00 13
17:7674872:C Y220C missense_variant 1.00 13
17:7675124:C Y163C missense_variant 1.00 13
17:7673776:A R282W missense_variant 1.00 13
17:7675076:C H179R missense_variant 1.00 12
17:7675190:T C141Y missense_variant 1.00 10
17:7673767:T E285K missense_variant 1.00 9
17:7673537:A Q331* stop_gained 1.00 9
17:7674250:T C238Y missense_variant 1.00 8
17:7674947:G I195T missense_variant 1.00 8
17:7674885:T V216M missense_variant 1.00 7
17:7673704:A R306* stop_gained 1.00 7
17:7674230:T G245S missense_variant 1.00 6
17:7674950:C L194R missense_variant 1.00 6
17:7673823:T G266E missense_variant 1.00 5
17:7673802:A R273L missense_variant 1.00 5
17:7673781:T R280K missense_variant 1.00 5
17:7675085:A C176F missense_variant 1.00 5
17:7674252:T M237I missense_variant 1.00 5
17:7674250:A C238F missense_variant 1.00 5
17:7674957:A Q192* stop_gained 1.00 5
17:7673806:T V272M missense_variant 1.00 4
17:7673809:T E271K missense_variant 1.00 4
17:7674229:T G245D missense_variant 1.00 4
17:7674873:G Y220H missense_variant 1.00 4
17:7673788:C P278A missense_variant 0.99 4
17:7674262:C Y234C missense_variant 0.99 4
17:7676037:G L111P missense_variant 0.99 4
17:7676048:T Y107* stop_gained 0.99 4
17:7674241:A S241F missense_variant 0.99 4
17:7675217:C K132R missense_variant 0.99 4
17:7675207:C C135W missense_variant 0.92 4
17:7670700:A R337C missense_variant 0.92 4
17:7673781:G R280T missense_variant 1.00 3
17:7673779:A D281Y missense_variant 1.00 3
17:7673796:T C275Y missense_variant 1.00 3
17:7674893:A R213L missense_variant 1.00 3
17:7674872:G Y220S missense_variant 1.00 3
17:7674921:A E204* stop_gained 1.00 3
17:7674917:C Y205C missense_variant 1.00 3
17:7674887:A S215I missense_variant 1.00 3
17:7674918:T Y205N missense_variant 1.00 3
17:7673740:A E294* stop_gained 1.00 3
17:7674935:A G199V missense_variant 1.00 3
17:7676031:C F113C missense_variant 1.00 3
17:7675161:A P151S missense_variant 0.99 3
17:7673787:A P278L missense_variant 0.99 3
17:7673788:A P278S missense_variant 0.99 3
17:7675218:C K132E missense_variant 0.99 3
17:7676210:T W53* stop_gained 0.99 3
17:7674261:T Y234* stop_gained 0.97 3
17:7675216:G K132N missense_variant 0.97 3
17:7670684:G R342P missense_variant 0.59 3
17:7675088:G R175P missense_variant 1.00 2
17:7673803:T R273S missense_variant 1.00 2
17:7673764:T E286K missense_variant 1.00 2
17:7673802:G R273P missense_variant 1.00 2
17:7673796:A C275F missense_variant 1.00 2
17:7673779:G D281H missense_variant 1.00 2
17:7674225:T M246I missense_variant 1.00 2
17:7674229:A G245V missense_variant 1.00 2
17:7675085:T C176Y missense_variant 1.00 2
17:7675174:T W146* stop_gained 1.00 2
17:7674252:A M237I missense_variant 1.00 2
17:7674953:A H193L missense_variant 1.00 2
17:7674230:A G245C missense_variant 1.00 2
17:7674232:T G244D missense_variant 1.00 2
17:7674918:G Y205H missense_variant 1.00 2
17:7673782:C R280G missense_variant 1.00 2
17:7674191:T E258K missense_variant 1.00 2
17:7675070:G R181P missense_variant 1.00 2
17:7676096:T W91* stop_gained 1.00 2
17:7676097:T W91* stop_gained 1.00 2
17:7675145:G R156P missense_variant 1.00 2
17:7676059:A Q104* stop_gained 1.00 2
17:7674954:A H193Y missense_variant 1.00 2
17:7674263:G Y234H missense_variant 1.00 2
17:7673778:C D281G missense_variant 1.00 2
17:7673579:A Q317* stop_gained 1.00 2
17:7675131:T A161T missense_variant 1.00 2
17:7675208:T C135Y missense_variant 0.99 2
17:7675208:A C135F missense_variant 0.99 2
17:7673788:T P278T missense_variant 0.99 2
17:7673764:A E286* stop_gained 0.99 2
17:7675077:A H179Y missense_variant 0.99 2
17:7675160:C P151R missense_variant 0.99 2
17:7674242:C S241A missense_variant 0.99 2
17:7674871:C Y220* stop_gained 0.99 2
17:7674241:C S241C missense_variant 0.99 2
17:7674189:G E258D missense_variant 0.99 2
17:7674870:A E221* stop_gained 0.99 2
17:7675206:A Q136* stop_gained 0.99 2
17:7674941:C V197G missense_variant 0.98 2
17:7675149:G T155P missense_variant 0.98 2
17:7675214:T M133K missense_variant 0.98 2
17:7676218:A E51* stop_gained 0.98 2
17:7674193:C L257R missense_variant 0.98 2
17:7673812:G F270L missense_variant 0.98 2
17:7675197:C K139E missense_variant 0.97 2
17:7676028:T L114* stop_gained 0.97 2
17:7674248:A N239Y missense_variant 0.97 2
17:7675119:A Q165* stop_gained 0.96 2
17:7675143:A V157F missense_variant 0.94 2
17:7674908:C D208G missense_variant 0.84 2
17:7673784:T G279E missense_variant 1.00 1
17:7675088:A R175L missense_variant 1.00 1
17:7673764:G E286Q missense_variant 1.00 1
17:7673823:A G266V missense_variant 1.00 1
17:7673809:G E271Q missense_variant 1.00 1
17:7673824:T G266R missense_variant 1.00 1
17:7673794:G A276P missense_variant 1.00 1
17:7674893:T R213Q missense_variant 1.00 1
17:7675095:A V173L missense_variant 1.00 1
17:7675095:T V173M missense_variant 1.00 1
17:7675109:G H168P missense_variant 1.00 1
17:7673811:G F270S missense_variant 1.00 1
17:7673763:G E286A missense_variant 1.00 1
17:7673763:A E286V missense_variant 1.00 1
17:7675997:T C124* stop_gained 1.00 1
17:7675139:T R158H missense_variant 1.00 1
17:7673552:A E326* stop_gained 1.00 1
17:7675089:C R175G missense_variant 1.00 1
17:7674948:A I195F missense_variant 1.00 1
17:7674238:A C242F missense_variant 1.00 1
17:7674233:A G244C missense_variant 1.00 1
17:7674918:C Y205D missense_variant 1.00 1
17:7675080:C H178D missense_variant 1.00 1
17:7675066:C C182W missense_variant 1.00 1
17:7674191:G E258Q missense_variant 1.00 1
17:7674221:C R248G missense_variant 1.00 1
17:7674873:T Y220N missense_variant 1.00 1
17:7674906:A R209* stop_gained 1.00 1
17:7675098:A V172F missense_variant 1.00 1
17:7675224:C L130V missense_variant 1.00 1
17:7674950:G L194P missense_variant 1.00 1
17:7674947:C I195S missense_variant 1.00 1
17:7674223:A N247I missense_variant 1.00 1
17:7674263:T Y234N missense_variant 1.00 1
17:7673778:A D281V missense_variant 1.00 1
17:7669668:A Q375* stop_gained 1.00 1
17:7675223:C L130R missense_variant 1.00 1
17:7675191:G C141R missense_variant 1.00 1
17:7675236:T Y126N missense_variant 1.00 1
17:7675200:G A138P missense_variant 0.99 1
17:7675995:T T125K missense_variant 0.99 1
17:7675995:C T125R missense_variant 0.99 1
17:7673787:C P278R missense_variant 0.99 1
17:7673793:T A276D missense_variant 0.99 1
17:7673547:T Y327* stop_gained 0.99 1
17:7675187:T P142H missense_variant 0.99 1
17:7673782:A R280* stop_gained 0.99 1
17:7673809:A E271* stop_gained 0.99 1
17:7673767:A E285* stop_gained 0.99 1
17:7675064:T S183* stop_gained 0.99 1
17:7675064:C S183* stop_gained 0.99 1
17:7675084:T C176* stop_gained 0.99 1
17:7676203:A E56* stop_gained 0.99 1
17:7675077:C H179D missense_variant 0.99 1
17:7674256:C Y236C missense_variant 0.99 1
17:7675160:T P151H missense_variant 0.99 1
17:7674242:T S241T missense_variant 0.99 1
17:7676032:C F113V missense_variant 0.99 1
17:7676037:T L111Q missense_variant 0.99 1
17:7675233:G S127P missense_variant 0.99 1
17:7675235:C Y126C missense_variant 0.99 1
17:7675232:A S127F missense_variant 0.99 1
17:7675232:T S127Y missense_variant 0.99 1
17:7676167:A E68* stop_gained 0.99 1
17:7673777:T D281E missense_variant 0.99 1
17:7676211:T W53* stop_gained 0.99 1
17:7675205:G Q136P missense_variant 0.99 1
17:7675217:G K132T missense_variant 0.99 1
17:7675136:A A159V missense_variant 0.99 1
17:7674208:G L252P missense_variant 0.99 1
17:7674216:G R249S missense_variant 0.99 1
17:7674216:A R249S missense_variant 0.99 1
17:7675206:C Q136E missense_variant 0.99 1
17:7675086:G C176R missense_variant 0.99 1
17:7676215:A Q52* stop_gained 0.99 1
17:7674191:A E258* stop_gained 0.98 1
17:7674942:T V197M missense_variant 0.98 1
17:7675084:C C176W missense_variant 0.98 1
17:7675130:T A161D missense_variant 0.98 1
17:7675209:G C135R missense_variant 0.98 1
17:7675209:C C135G missense_variant 0.98 1
17:7675214:C M133R missense_variant 0.98 1
17:7674268:C I232S missense_variant 0.98 1
17:7674199:C I255S missense_variant 0.98 1
17:7674199:T I255N missense_variant 0.98 1
17:7674211:C I251S missense_variant 0.98 1
17:7673812:T F270I missense_variant 0.98 1
17:7673799:T V274D missense_variant 0.98 1
17:7673799:C V274G missense_variant 0.98 1
17:7674939:A E198* stop_gained 0.98 1
17:7673826:C L265R missense_variant 0.97 1
17:7673826:G L265P missense_variant 0.97 1
17:7674861:A E224* stop_gained 0.97 1
17:7673755:A L289F missense_variant 0.97 1
17:7673780:G R280S missense_variant 0.97 1
17:7676257:A Q38* stop_gained 0.97 1
17:7676040:G R110P missense_variant 0.97 1
17:7675182:A Q144* stop_gained 0.97 1
17:7674247:C N239S missense_variant 0.97 1
17:7673567:A K321* stop_gained 0.96 1
17:7674257:G Y236H missense_variant 0.96 1
17:7676176:A R65* stop_gained 0.96 1
17:7673759:A E287D missense_variant 0.96 1
17:7675097:T V172D missense_variant 0.94 1
17:7675142:C V157G missense_variant 0.94 1
17:7675125:C Y163D missense_variant 0.94 1
17:7675142:T V157D missense_variant 0.94 1
17:7675189:C C141W missense_variant 0.94 1
17:7676041:A R110C missense_variant 0.93 1
17:7675113:A Q167* stop_gained 0.93 1
17:7676050:C Y107D missense_variant 0.92 1
17:7673800:A V274F missense_variant 0.92 1
17:7675105:T M169I missense_variant 0.91 1
17:7675140:C R158G missense_variant 0.91 1
17:7676071:A Q100* stop_gained 0.90 1
17:7674239:C C242G missense_variant 0.90 1
17:7674214:A P250L missense_variant 0.89 1
17:7673573:A K319* stop_gained 0.88 1
17:7674200:A I255F missense_variant 0.82 1
17:7675122:A K164* stop_gained 0.81 1
17:7675211:G F134S missense_variant 0.77 1
17:7673795:T C275* stop_gained 0.77 1
17:7676038:C L111V missense_variant 0.72 1
17:7674249:T C238* stop_gained 0.72 1
17:7674878:T V218E missense_variant 0.55 1
17:7674859:T E224E splice_region_variant 1.00 0
17:7673784:G G279A missense_variant 1.00 0
17:7673784:A G279V missense_variant 1.00 0
17:7674220:A R248L missense_variant 1.00 0
17:7674220:G R248P missense_variant 1.00 0
17:7673806:G V272L missense_variant 1.00 0
17:7673806:A V272L missense_variant 1.00 0
17:7673775:T R282Q missense_variant 1.00 0
17:7673775:G R282P missense_variant 1.00 0
17:7673775:A R282L missense_variant 1.00 0
17:7673803:C R273G missense_variant 1.00 0
17:7673760:A E287V missense_variant 1.00 0
17:7673760:C E287G missense_variant 1.00 0
17:7673760:G E287A missense_variant 1.00 0
17:7673779:T D281N missense_variant 1.00 0
17:7673824:G G266R missense_variant 1.00 0
17:7673823:G G266A missense_variant 1.00 0
17:7673796:G C275S missense_variant 1.00 0
17:7673785:T G279R missense_variant 1.00 0
17:7673785:G G279R missense_variant 1.00 0
17:7673781:A R280I missense_variant 1.00 0
17:7673767:G E285Q missense_variant 1.00 0
17:7673785:A G279W missense_variant 1.00 0
17:7673794:A A276S missense_variant 1.00 0
17:7673794:T A276T missense_variant 1.00 0
17:7674225:A M246I missense_variant 1.00 0
17:7674229:G G245A missense_variant 1.00 0
17:7674225:G M246I missense_variant 1.00 0
17:7674893:G R213P missense_variant 1.00 0
17:7675095:G V173L missense_variant 1.00 0
17:7675085:G C176S missense_variant 1.00 0
17:7674872:A Y220F missense_variant 1.00 0
17:7674885:G V216L missense_variant 1.00 0
17:7674885:A V216L missense_variant 1.00 0
17:7675124:A Y163F missense_variant 1.00 0
17:7675124:G Y163S missense_variant 1.00 0
17:7675109:C H168R missense_variant 1.00 0
17:7675109:A H168L missense_variant 1.00 0
17:7673811:C F270C missense_variant 1.00 0
17:7673811:T F270Y missense_variant 1.00 0
17:7673763:C E286G missense_variant 1.00 0
17:7674222:C N247K missense_variant 1.00 0
17:7674222:T N247K missense_variant 1.00 0
17:7673761:T E287K missense_variant 1.00 0
17:7673761:G E287Q missense_variant 1.00 0
17:7674917:G Y205S missense_variant 1.00 0
17:7674917:A Y205F missense_variant 1.00 0
17:7675076:A H179L missense_variant 1.00 0
17:7675076:G H179P missense_variant 1.00 0
17:7675139:G R158P missense_variant 1.00 0
17:7675139:A R158L missense_variant 1.00 0
17:7674250:G C238S missense_variant 1.00 0
17:7674252:G M237I missense_variant 1.00 0
17:7673776:C R282G missense_variant 1.00 0
17:7675089:T R175S missense_variant 1.00 0
17:7675089:A R175C missense_variant 1.00 0
17:7675190:G C141S missense_variant 1.00 0
17:7675190:A C141F missense_variant 1.00 0
17:7674190:G E258A missense_variant 1.00 0
17:7674190:C E258G missense_variant 1.00 0
17:7674190:A E258V missense_variant 1.00 0
17:7674953:G H193P missense_variant 1.00 0
17:7674948:G I195L missense_variant 1.00 0
17:7674948:C I195V missense_variant 1.00 0
17:7673749:A K291* stop_gained 1.00 0
17:7674217:G R249T missense_variant 1.00 0
17:7674217:T R249K missense_variant 1.00 0
17:7674217:A R249M missense_variant 1.00 0
17:7675071:T R181S missense_variant 1.00 0
17:7675071:C R181G missense_variant 1.00 0
17:7675071:A R181C missense_variant 1.00 0
17:7674888:C S215G missense_variant 1.00 0
17:7674887:G S215T missense_variant 1.00 0
17:7674887:T S215N missense_variant 1.00 0
17:7674888:A S215C missense_variant 1.00 0
17:7674888:G S215R missense_variant 1.00 0
17:7674238:T C242Y missense_variant 1.00 0
17:7674232:A G244V missense_variant 1.00 0
17:7674232:G G244A missense_variant 1.00 0
17:7674233:G G244R missense_variant 1.00 0
17:7674233:T G244S missense_variant 1.00 0
17:7674238:G C242S missense_variant 1.00 0
17:7674230:G G245R missense_variant 1.00 0
17:7675106:T M169K missense_variant 1.00 0
17:7675106:C M169R missense_variant 1.00 0
17:7675106:G M169T missense_variant 1.00 0
17:7674951:T L194I missense_variant 1.00 0
17:7674951:A L194F missense_variant 1.00 0
17:7674951:C L194V missense_variant 1.00 0
17:7675080:T H178N missense_variant 1.00 0
17:7675080:A H178Y missense_variant 1.00 0
17:7675070:T R181H missense_variant 1.00 0
17:7675070:A R181L missense_variant 1.00 0
17:7675066:T C182* stop_gained 1.00 0
17:7670703:A E336* stop_gained 1.00 0
17:7676068:A K101* stop_gained 1.00 0
17:7674873:C Y220D missense_variant 1.00 0
17:7674884:G V216A missense_variant 1.00 0
17:7674884:T V216E missense_variant 1.00 0
17:7674884:C V216G missense_variant 1.00 0
17:7673570:A K320* stop_gained 1.00 0
17:7674894:C R213G missense_variant 1.00 0
17:7675098:G V172L missense_variant 1.00 0
17:7675098:T V172I missense_variant 1.00 0
17:7675137:A A159S missense_variant 1.00 0
17:7675137:G A159P missense_variant 1.00 0
17:7675137:T A159T missense_variant 1.00 0
17:7675145:T R156H missense_variant 1.00 0
17:7675145:A R156L missense_variant 1.00 0
17:7673762:G E286D missense_variant 1.00 0
17:7673762:A E286D missense_variant 1.00 0
17:7675224:T L130I missense_variant 1.00 0
17:7675224:A L130F missense_variant 1.00 0
17:7675079:A H178L missense_variant 1.00 0
17:7675079:C H178R missense_variant 1.00 0
17:7675079:G H178P missense_variant 1.00 0
17:7674947:T I195N missense_variant 1.00 0
17:7674950:T L194H missense_variant 1.00 0
17:7674227:C M246V missense_variant 1.00 0
17:7674223:C N247S missense_variant 1.00 0
17:7674223:G N247T missense_variant 1.00 0
17:7674224:A N247Y missense_variant 1.00 0
17:7674224:C N247D missense_variant 1.00 0
17:7674224:G N247H missense_variant 1.00 0
17:7674227:G M246L missense_variant 1.00 0
17:7674227:A M246L missense_variant 1.00 0
17:7674954:T H193N missense_variant 1.00 0
17:7674954:C H193D missense_variant 1.00 0
17:7675199:C A138G missense_variant 1.00 0
17:7675199:A A138V missense_variant 1.00 0
17:7675199:T A138D missense_variant 1.00 0
17:7674263:C Y234D missense_variant 1.00 0
17:7673808:C E271G missense_variant 1.00 0
17:7673808:A E271V missense_variant 1.00 0
17:7673766:A E285V missense_variant 1.00 0
17:7673766:C E285G missense_variant 1.00 0
17:7673766:G E285A missense_variant 1.00 0
17:7673778:G D281A missense_variant 1.00 0
17:7673808:G E271A missense_variant 1.00 0
17:7670658:A K351* stop_gained 1.00 0
17:7675207:T C135* stop_gained 1.00 0
17:7673746:A K292* stop_gained 1.00 0
17:7675189:T C141* stop_gained 1.00 0
17:7674936:T G199R missense_variant 1.00 0
17:7674936:G G199R missense_variant 1.00 0
17:7674935:T G199E missense_variant 1.00 0
17:7674935:G G199A missense_variant 1.00 0
17:7675223:G L130P missense_variant 1.00 0
17:7675223:T L130H missense_variant 1.00 0
17:7676525:A K24* stop_gained 1.00 0
17:7676031:T F113Y missense_variant 1.00 0
17:7676031:G F113S missense_variant 1.00 0
17:7674246:C N239K missense_variant 1.00 0
17:7674246:T N239K missense_variant 1.00 0
17:7675191:C C141G missense_variant 1.00 0
17:7675191:T C141S missense_variant 1.00 0
17:7675236:C Y126D missense_variant 1.00 0
17:7675236:G Y126H missense_variant 1.00 0
17:7675131:A A161S missense_variant 1.00 0
17:7675131:G A161P missense_variant 1.00 0
17:7676185:A E62* stop_gained 1.00 0
17:7675161:T P151T missense_variant 0.99 0
17:7675161:C P151A missense_variant 0.99 0
17:7675200:A A138S missense_variant 0.99 0
17:7675208:G C135S missense_variant 0.99 0
17:7675200:T A138T missense_variant 0.99 0
17:7675995:A T125M missense_variant 0.99 0
17:7673793:A A276V missense_variant 0.99 0
17:7673787:T P278H missense_variant 0.99 0
17:7673793:C A276G missense_variant 0.99 0
17:7673547:C Y327* stop_gained 0.99 0
17:7675187:C P142R missense_variant 0.99 0
17:7675187:A P142L missense_variant 0.99 0
17:7673824:A G266* stop_gained 0.99 0
17:7675077:T H179N missense_variant 0.99 0
17:7674262:G Y234S missense_variant 0.99 0
17:7674262:A Y234F missense_variant 0.99 0
17:7675175:T W146* stop_gained 0.99 0
17:7674256:G Y236S missense_variant 0.99 0
17:7674256:A Y236F missense_variant 0.99 0
17:7675160:A P151L missense_variant 0.99 0
17:7673807:G E271D missense_variant 0.99 0
17:7673807:A E271D missense_variant 0.99 0
17:7674242:G S241P missense_variant 0.99 0
17:7676037:C L111R missense_variant 0.99 0
17:7676032:G F113L missense_variant 0.99 0
17:7676032:T F113I missense_variant 0.99 0
17:7674929:T L201* stop_gained 0.99 0
17:7675233:T S127T missense_variant 0.99 0
17:7675233:C S127A missense_variant 0.99 0
17:7674871:T Y220* stop_gained 0.99 0
17:7674267:C I232M missense_variant 0.99 0
17:7675235:G Y126S missense_variant 0.99 0
17:7675235:A Y126F missense_variant 0.99 0
17:7676048:C Y107* stop_gained 0.99 0
17:7674241:T S241Y missense_variant 0.99 0
17:7676591:A E2* stop_gained 0.99 0
17:7674189:A E258D missense_variant 0.99 0
17:7670640:A K357* stop_gained 0.99 0
17:7675232:C S127C missense_variant 0.99 0
17:7675234:T Y126* stop_gained 0.99 0
17:7675234:C Y126* stop_gained 0.99 0
17:7673777:C D281E missense_variant 0.99 0
17:7676265:T L35* stop_gained 0.99 0
17:7675205:A Q136L missense_variant 0.99 0
17:7675205:C Q136R missense_variant 0.99 0
17:7675217:A K132M missense_variant 0.99 0
17:7675218:G K132Q missense_variant 0.99 0
17:7673535:T Q331Q splice_region_variant 0.99 0
17:7675136:T A159D missense_variant 0.99 0
17:7675136:C A159G missense_variant 0.99 0
17:7674936:A G199* stop_gained 0.99 0
17:7674208:C L252R missense_variant 0.99 0
17:7674208:T L252H missense_variant 0.99 0
17:7674914:T L206* stop_gained 0.99 0
17:7675206:T Q136K missense_variant 0.99 0
17:7675188:A P142S missense_variant 0.99 0
17:7675188:C P142A missense_variant 0.99 0
17:7675188:T P142T missense_variant 0.99 0
17:7675086:T C176S missense_variant 0.99 0
17:7675094:G V173A missense_variant 0.99 0
17:7675086:C C176G missense_variant 0.99 0
17:7675094:C V173G missense_variant 0.99 0
17:7675094:T V173E missense_variant 0.99 0
17:7675078:T H178Q missense_variant 0.99 0
17:7675078:C H178Q missense_variant 0.99 0
17:7674226:G M246T missense_variant 0.99 0
17:7674226:C M246R missense_variant 0.99 0
17:7674226:T M246K missense_variant 0.99 0
17:7674941:G V197A missense_variant 0.98 0
17:7674941:T V197E missense_variant 0.98 0
17:7674942:G V197L missense_variant 0.98 0
17:7674942:A V197L missense_variant 0.98 0
17:7674916:T Y205* stop_gained 0.98 0
17:7674916:C Y205* stop_gained 0.98 0
17:7675218:A K132* stop_gained 0.98 0
17:7675149:C T155A missense_variant 0.98 0
17:7675149:A T155S missense_variant 0.98 0
17:7675148:A T155I missense_variant 0.98 0
17:7675148:C T155S missense_variant 0.98 0
17:7675148:T T155N missense_variant 0.98 0
17:7675130:A A161V missense_variant 0.98 0
17:7675130:C A161G missense_variant 0.98 0
17:7675209:T C135S missense_variant 0.98 0
17:7675214:G M133T missense_variant 0.98 0
17:7675212:T F134I missense_variant 0.98 0
17:7675212:G F134L missense_variant 0.98 0
17:7675212:C F134V missense_variant 0.98 0
17:7674251:C C238G missense_variant 0.98 0
17:7674251:G C238R missense_variant 0.98 0
17:7674251:T C238S missense_variant 0.98 0
17:7674253:C M237R missense_variant 0.98 0
17:7674253:G M237T missense_variant 0.98 0
17:7674253:T M237K missense_variant 0.98 0
17:7673761:A E287* stop_gained 0.98 0
17:7676546:A E17* stop_gained 0.98 0
17:7674268:T I232N missense_variant 0.98 0
17:7674268:G I232T missense_variant 0.98 0
17:7675075:T H179Q missense_variant 0.98 0
17:7675075:C H179Q missense_variant 0.98 0
17:7674199:G I255T missense_variant 0.98 0
17:7674193:T L257Q missense_variant 0.98 0
17:7674193:G L257P missense_variant 0.98 0
17:7674211:G I251T missense_variant 0.98 0
17:7674211:T I251N missense_variant 0.98 0
17:7675196:A K139M missense_variant 0.98 0
17:7675196:G K139T missense_variant 0.98 0
17:7675196:C K139R missense_variant 0.98 0
17:7675996:C T125A missense_variant 0.98 0
17:7675996:A T125S missense_variant 0.98 0
17:7675996:G T125P missense_variant 0.98 0
17:7673797:T C275S missense_variant 0.98 0
17:7673799:G V274A missense_variant 0.98 0
17:7673812:C F270V missense_variant 0.98 0
17:7673797:G C275R missense_variant 0.98 0
17:7673797:C C275G missense_variant 0.98 0
17:7675067:A C182F missense_variant 0.98 0
17:7675067:G C182S missense_variant 0.98 0
17:7675067:T C182Y missense_variant 0.98 0
17:7674218:C R249G missense_variant 0.97 0
17:7674218:A R249W missense_variant 0.97 0
17:7675197:G K139Q missense_variant 0.97 0
17:7673826:T L265Q missense_variant 0.97 0
17:7673755:C L289V missense_variant 0.97 0
17:7673755:T L289I missense_variant 0.97 0
17:7669629:A E388* stop_gained 0.97 0
17:7673780:A R280S missense_variant 0.97 0
17:7673728:A E298* stop_gained 0.97 0
17:7676396:A E28* stop_gained 0.97 0
17:7674261:C Y234* stop_gained 0.97 0
17:7676564:A E11* stop_gained 0.97 0
17:7674198:C I255M missense_variant 0.97 0
17:7676040:T R110H missense_variant 0.97 0
17:7676040:A R110L missense_variant 0.97 0
17:7676582:A Q5* stop_gained 0.97 0
17:7675216:A K132N missense_variant 0.97 0
17:7670673:A E346* stop_gained 0.97 0
17:7673795:C C275W missense_variant 0.97 0
17:7674255:C Y236* stop_gained 0.97 0
17:7674255:T Y236* stop_gained 0.97 0
17:7674237:C C242W missense_variant 0.97 0
17:7675146:T R156S missense_variant 0.97 0
17:7675146:C R156G missense_variant 0.97 0
17:7675146:A R156C missense_variant 0.97 0
17:7674247:A N239I missense_variant 0.97 0
17:7674254:G M237L missense_variant 0.97 0
17:7674254:C M237V missense_variant 0.97 0
17:7674254:A M237L missense_variant 0.97 0
17:7674248:G N239H missense_variant 0.97 0
17:7674248:C N239D missense_variant 0.97 0
17:7674247:G N239T missense_variant 0.97 0
17:7670664:A E349* stop_gained 0.96 0
17:7675101:A E171* stop_gained 0.96 0
17:7674257:T Y236N missense_variant 0.96 0
17:7674257:C Y236D missense_variant 0.96 0
17:7673759:G E287D missense_variant 0.96 0
17:7673827:C L265V missense_variant 0.96 0
17:7673827:T L265M missense_variant 0.96 0
17:7674946:C I195M missense_variant 0.96 0
17:7674212:G I251L missense_variant 0.96 0
17:7674212:C I251V missense_variant 0.96 0
17:7674212:A I251F missense_variant 0.96 0
17:7675107:C M169V missense_variant 0.96 0
17:7675107:A M169L missense_variant 0.96 0
17:7675107:G M169L missense_variant 0.96 0
17:7675068:T C182S missense_variant 0.95 0
17:7675068:C C182G missense_variant 0.95 0
17:7675068:G C182R missense_variant 0.95 0
17:7674909:A D208Y missense_variant 0.95 0
17:7674909:T D208N missense_variant 0.95 0
17:7674909:G D208H missense_variant 0.95 0
17:7670666:T L348* stop_gained 0.95 0
17:7675123:C Y163* stop_gained 0.95 0
17:7675123:T Y163* stop_gained 0.95 0
17:7673555:A G325* stop_gained 0.94 0
17:7675125:T Y163N missense_variant 0.94 0
17:7675097:C V172G missense_variant 0.94 0
17:7675142:G V157A missense_variant 0.94 0
17:7675097:G V172A missense_variant 0.94 0
17:7675125:G Y163H missense_variant 0.94 0
17:7670682:A E343* stop_gained 0.94 0
17:7673765:G E285D missense_variant 0.94 0
17:7673765:A E285D missense_variant 0.94 0
17:7675143:T V157I missense_variant 0.94 0
17:7675143:G V157L missense_variant 0.94 0
17:7670694:A E339* stop_gained 0.93 0
17:7675197:A K139* stop_gained 0.93 0
17:7676041:C R110G missense_variant 0.93 0
17:7676041:T R110S missense_variant 0.93 0
17:7673805:G V272A missense_variant 0.93 0
17:7673805:C V272G missense_variant 0.93 0
17:7673805:T V272E missense_variant 0.93 0
17:7673790:T C277Y missense_variant 0.92 0
17:7673790:G C277S missense_variant 0.92 0
17:7673790:A C277F missense_variant 0.92 0
17:7676050:T Y107N missense_variant 0.92 0
17:7676050:G Y107H missense_variant 0.92 0
17:7670700:T R337S missense_variant 0.92 0
17:7670700:C R337G missense_variant 0.92 0
17:7673800:T V274I missense_variant 0.92 0
17:7673800:G V274L missense_variant 0.92 0
17:7675105:G M169I missense_variant 0.91 0
17:7675105:A M169I missense_variant 0.91 0
17:7675140:T R158S missense_variant 0.91 0
17:7675140:A R158C missense_variant 0.91 0
17:7675074:A E180* stop_gained 0.91 0
17:7676578:T S6* stop_gained 0.91 0
17:7676578:C S6* stop_gained 0.91 0
17:7675110:T H168N missense_variant 0.91 0
17:7675110:C H168D missense_variant 0.91 0
17:7675110:A H168Y missense_variant 0.91 0
17:7674237:T C242* stop_gained 0.90 0
17:7674969:A L188L splice_region_variant 0.90 0
17:7674239:T C242S missense_variant 0.90 0
17:7674239:G C242R missense_variant 0.90 0
17:7676011:A K120* stop_gained 0.90 0
17:7674214:T P250H missense_variant 0.89 0
17:7674214:C P250R missense_variant 0.89 0
17:7674215:A P250S missense_variant 0.89 0
17:7674215:C P250A missense_variant 0.89 0
17:7674215:T P250T missense_variant 0.89 0
17:7673810:T F270L missense_variant 0.89 0
17:7673810:C F270L missense_variant 0.89 0
17:7673789:T C277* stop_gained 0.88 0
17:7673754:C L289R missense_variant 0.86 0
17:7673754:T L289H missense_variant 0.86 0
17:7673754:G L289P missense_variant 0.86 0
17:7676549:A Q16* stop_gained 0.86 0
17:7675204:G Q136H missense_variant 0.86 0
17:7675204:A Q136H missense_variant 0.86 0
17:7676382:A L32L splice_region_variant 0.85 0
17:7676382:G L32L splice_region_variant 0.85 0
17:7676382:T L32L splice_region_variant 0.85 0
17:7674890:C H214R missense_variant 0.84 0
17:7674908:A D208V missense_variant 0.84 0
17:7674890:A H214L missense_variant 0.84 0
17:7674890:G H214P missense_variant 0.84 0
17:7674908:G D208A missense_variant 0.84 0
17:7676088:C S94* stop_gained 0.84 0
17:7676088:T S94* stop_gained 0.84 0
17:7670649:A Q354* stop_gained 0.83 0
17:7675108:C H168Q missense_variant 0.83 0
17:7675108:T H168Q missense_variant 0.83 0
17:7674200:G I255L missense_variant 0.82 0
17:7674200:C I255V missense_variant 0.82 0
17:7676522:A L25L splice_region_variant 0.81 0
17:7674276:T C229* stop_gained 0.80 0
17:7675215:C M133V missense_variant 0.80 0
17:7675215:A M133L missense_variant 0.80 0
17:7675215:G M133L missense_variant 0.80 0
17:7673820:G R267P missense_variant 0.80 0
17:7673820:A R267L missense_variant 0.80 0
17:7673820:T R267Q missense_variant 0.80 0
17:7673702:A R306R splice_region_variant 0.79 0
17:7673702:G R306R splice_region_variant 0.79 0
17:7673702:C R306R splice_region_variant 0.79 0
17:7675234:A Y126Y splice_region_variant 0.77 0
17:7675211:T F134Y missense_variant 0.77 0
17:7675211:C F134C missense_variant 0.77 0
17:7675101:G E171Q missense_variant 0.77 0
17:7675101:T E171K missense_variant 0.77 0
17:7670713:T I332I splice_region_variant 0.76 0
17:7670713:A I332I splice_region_variant 0.76 0
17:7673707:A K305* stop_gained 0.76 0
17:7674249:C C238W missense_variant 0.75 0
17:7675195:G K139N missense_variant 0.74 0
17:7675195:A K139N missense_variant 0.74 0
17:7673833:A N263Y missense_variant 0.73 0
17:7673833:G N263H missense_variant 0.73 0
17:7673833:C N263D missense_variant 0.73 0
17:7674269:G I232L missense_variant 0.73 0
17:7674269:C I232V missense_variant 0.73 0
17:7674269:A I232F missense_variant 0.73 0
17:7669690:A S367S splice_region_variant 0.73 0
17:7676527:T W23* stop_gained 0.72 0
17:7676038:T L111M missense_variant 0.72 0
17:7674209:A L252F missense_variant 0.71 0
17:7674209:C L252V missense_variant 0.71 0
17:7674209:T L252I missense_variant 0.71 0
17:7675055:C D186G missense_variant 0.70 0
17:7675055:A D186V missense_variant 0.70 0
17:7675055:G D186A missense_variant 0.70 0
17:7676536:T S20* stop_gained 0.70 0
17:7676536:C S20* stop_gained 0.70 0
17:7674183:C S260S splice_region_variant 0.68 0
17:7674183:A S260S splice_region_variant 0.68 0
17:7674183:T S260S splice_region_variant 0.68 0
17:7676030:C F113L missense_variant 0.65 0
17:7676030:T F113L missense_variant 0.65 0
17:7676049:G Y107S missense_variant 0.64 0
17:7676049:A Y107F missense_variant 0.64 0
17:7676049:C Y107C missense_variant 0.64 0
17:7675210:C F134L missense_variant 0.64 0
17:7675210:T F134L missense_variant 0.64 0
17:7674886:C S215R missense_variant 0.64 0
17:7674886:T S215R missense_variant 0.64 0
17:7676384:A L32L splice_region_variant 0.61 0
17:7674907:C D208E missense_variant 0.60 0
17:7674907:T D208E missense_variant 0.60 0
17:7676588:A E3* stop_gained 0.60 0
17:7676526:T W23* stop_gained 0.60 0
17:7676241:T L43* stop_gained 0.60 0
17:7670684:A R342L missense_variant 0.59 0
17:7670684:T R342Q missense_variant 0.59 0
17:7676060:C Y103* stop_gained 0.59 0
17:7676060:T Y103* stop_gained 0.59 0
17:7669674:A K373* stop_gained 0.58 0
17:7669635:A K386* stop_gained 0.58 0
17:7669677:A K372* stop_gained 0.58 0
17:7669647:A K382* stop_gained 0.58 0
17:7669683:A K370* stop_gained 0.58 0
17:7674878:G V218A missense_variant 0.55 0
17:7674878:C V218G missense_variant 0.55 0
17:7674891:T H214N missense_variant 0.54 0
17:7674891:A H214Y missense_variant 0.54 0
17:7674891:C H214D missense_variant 0.54 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(BRCA) Breast adenocarcinoma BRCA 0.66 0.41