Top
CDH1 BRCA ×
Select a mutation to see further information
Mutation AA change Consequence type BoostDM score IntOGen frequency
16:68738315:T Q23* stop_gained 1.00 16
16:68801693:T R63* stop_gained 1.00 6
16:68810272:T Q255* stop_gained 1.00 4
16:68801891:T Q129* stop_gained 1.00 3
16:68815725:T Q511* stop_gained 1.00 3
16:68822210:T Q641* stop_gained 1.00 2
16:68801726:T R74* stop_gained 1.00 2
16:68823479:T Q673* stop_gained 1.00 2
16:68815674:T E494* stop_gained 1.00 2
16:68819283:G Y523* stop_gained 1.00 1
16:68811854:T R335* stop_gained 1.00 1
16:68808744:T Q195* stop_gained 1.00 1
16:68737461:T Q16* stop_gained 1.00 1
16:68815701:T Q503* stop_gained 1.00 1
16:68823464:T K668* stop_gained 1.00 1
16:68815536:T Q448* stop_gained 1.00 1
16:68822117:T Q610* stop_gained 1.00 1
16:68833402:G S851* stop_gained 1.00 1
16:68811859:A E336E splice_region_variant 1.00 1
16:68823401:T Q647* stop_gained 1.00 1
16:68810341:T G278* stop_gained 1.00 1
16:68810290:T E261* stop_gained 1.00 1
16:68801815:A W103* stop_gained 1.00 1
16:68801710:A Y68* stop_gained 1.00 1
16:68823557:T Q699* stop_gained 1.00 1
16:68833355:A Y835* stop_gained 1.00 1
16:68737441:A S9* stop_gained 1.00 1
16:68812263:A T379T splice_region_variant 0.99 1
16:68738308:A W20* stop_gained 1.00 0
16:68808720:T K187* stop_gained 1.00 0
16:68815581:T E463* stop_gained 1.00 0
16:68808731:A Y190* stop_gained 1.00 0
16:68808731:G Y190* stop_gained 1.00 0
16:68808442:T Q136* stop_gained 1.00 0
16:68819314:T E534* stop_gained 1.00 0
16:68812162:T Q346* stop_gained 1.00 0
16:68815668:T R492* stop_gained 1.00 0
16:68819292:A W526* stop_gained 1.00 0
16:68813364:T K397* stop_gained 1.00 0
16:68819397:G Y561* stop_gained 1.00 0
16:68819397:A Y561* stop_gained 1.00 0
16:68819283:A Y523* stop_gained 1.00 0
16:68738359:A Y37* stop_gained 1.00 0
16:68738359:G Y37* stop_gained 1.00 0
16:68813495:A K440K splice_region_variant 1.00 0
16:68815662:T E490* stop_gained 1.00 0
16:68808786:T R209* stop_gained 1.00 0
16:68828271:A Y754* stop_gained 1.00 0
16:68819353:T E547* stop_gained 1.00 0
16:68828271:G Y754* stop_gained 1.00 0
16:68823485:T K675* stop_gained 1.00 0
16:68808567:A Q177Q splice_region_variant 1.00 0
16:68815704:T E504* stop_gained 1.00 0
16:68833404:T E852* stop_gained 1.00 0
16:68811739:A Y296* stop_gained 1.00 0
16:68811739:G Y296* stop_gained 1.00 0
16:68815665:T K491* stop_gained 1.00 0
16:68823578:T Q706* stop_gained 1.00 0
16:68833408:A S853* stop_gained 1.00 0
16:68833408:G S853* stop_gained 1.00 0
16:68738314:A C22* stop_gained 1.00 0
16:68808484:T R150* stop_gained 1.00 0
16:68822111:T K608* stop_gained 1.00 0
16:68815539:T Q449* stop_gained 1.00 0
16:68813422:A L416* stop_gained 1.00 0
16:68808490:T Q152* stop_gained 1.00 0
16:68823566:T E702* stop_gained 1.00 0
16:68808487:T R151* stop_gained 1.00 0
16:68801732:T K76* stop_gained 1.00 0
16:68833413:T K855* stop_gained 1.00 0
16:68808436:T G134* stop_gained 1.00 0
16:68823551:T K697* stop_gained 1.00 0
16:68801827:G Y107* stop_gained 1.00 0
16:68801827:A Y107* stop_gained 1.00 0
16:68819383:T K557* stop_gained 1.00 0
16:68819293:T R527* stop_gained 1.00 0
16:68738307:A W20* stop_gained 1.00 0
16:68822098:A C603* stop_gained 1.00 0
16:68801678:T E58* stop_gained 1.00 0
16:68813436:T G421* stop_gained 1.00 0
16:68808705:T K182* stop_gained 1.00 0
16:68819291:A W526* stop_gained 1.00 0
16:68738351:T E35* stop_gained 1.00 0
16:68808789:T E210* stop_gained 1.00 0
16:68801789:T Q95* stop_gained 1.00 0
16:68738387:T E47* stop_gained 1.00 0
16:68810216:G S236* stop_gained 1.00 0
16:68810216:A S236* stop_gained 1.00 0
16:68828304:A Q765Q splice_region_variant 1.00 0
16:68808538:T K168* stop_gained 1.00 0
16:68738318:T E24* stop_gained 1.00 0
16:68801843:T K113* stop_gained 1.00 0
16:68822099:T E604* stop_gained 1.00 0
16:68823425:T K655* stop_gained 1.00 0
16:68823419:T K653* stop_gained 1.00 0
16:68808804:T K215* stop_gained 1.00 0
16:68801696:T Q64* stop_gained 1.00 0
16:68812190:A L355* stop_gained 1.00 0
16:68812190:G L355* stop_gained 1.00 0
16:68801828:T R108* stop_gained 1.00 0
16:68813414:A Y413* stop_gained 1.00 0
16:68813414:G Y413* stop_gained 1.00 0
16:68833433:A Y861* stop_gained 1.00 0
16:68833433:G Y861* stop_gained 1.00 0
16:68808799:A W213* stop_gained 1.00 0
16:68808553:T K173* stop_gained 1.00 0
16:68738324:T E26* stop_gained 1.00 0
16:68815533:T K447* stop_gained 1.00 0
16:68808825:T R222* stop_gained 1.00 0
16:68810284:T K259* stop_gained 1.00 0
16:68833402:A S851* stop_gained 1.00 0
16:68828209:T R734* stop_gained 1.00 0
16:68833296:T K816* stop_gained 1.00 0
16:68813493:T K440* stop_gained 1.00 0
16:68813331:T E386* stop_gained 1.00 0
16:68828268:G Y753* stop_gained 1.00 0
16:68828268:A Y753* stop_gained 1.00 0
16:68829664:A L769* stop_gained 1.00 0
16:68801686:A C60* stop_gained 1.00 0
16:68823506:T E682* stop_gained 1.00 0
16:68808535:T E167* stop_gained 1.00 0
16:68812149:G Y341* stop_gained 1.00 0
16:68812149:A Y341* stop_gained 1.00 0
16:68812177:T Q351* stop_gained 1.00 0
16:68811698:T E283* stop_gained 1.00 0
16:68808525:A C163* stop_gained 1.00 0
16:68833419:T Q857* stop_gained 1.00 0
16:68808452:A L139* stop_gained 1.00 0
16:68823527:T E689* stop_gained 1.00 0
16:68738390:T R48* stop_gained 1.00 0
16:68828281:T E758* stop_gained 1.00 0
16:68823572:T G704* stop_gained 1.00 0
16:68808783:T E208* stop_gained 1.00 0
16:68811770:T Q307* stop_gained 1.00 0
16:68829774:T E806* stop_gained 1.00 0
16:68813401:A W409* stop_gained 1.00 0
16:68813402:A W409* stop_gained 1.00 0
16:68819365:T E551* stop_gained 1.00 0
16:68808845:A Y228* stop_gained 1.00 0
16:68808845:G Y228* stop_gained 1.00 0
16:68828231:G L741* stop_gained 1.00 0
16:68828231:A L741* stop_gained 1.00 0
16:68813439:T Q422* stop_gained 1.00 0
16:68833440:T E864* stop_gained 1.00 0
16:68828302:T Q765* stop_gained 1.00 0
16:68808696:T K179* stop_gained 1.00 0
16:68829795:T E813* stop_gained 1.00 0
16:68808800:A W213* stop_gained 1.00 0
16:68828242:T E745* stop_gained 1.00 0
16:68829780:T G808* stop_gained 1.00 0
16:68828224:T E739* stop_gained 1.00 0
16:68801831:T K109* stop_gained 1.00 0
16:68813484:T K437* stop_gained 1.00 0
16:68833458:T K870* stop_gained 1.00 0
16:68828221:T K738* stop_gained 1.00 0
16:68815544:A Y450* stop_gained 1.00 0
16:68815544:G Y450* stop_gained 1.00 0
16:68808565:T Q177* stop_gained 1.00 0
16:68833371:T E841* stop_gained 1.00 0
16:68823576:A L705* stop_gained 1.00 0
16:68801814:A W103* stop_gained 1.00 0
16:68822081:T R598* stop_gained 1.00 0
16:68801762:T K86* stop_gained 1.00 0
16:68823608:T G716* stop_gained 1.00 0
16:68829669:T Q771* stop_gained 1.00 0
16:68813482:A L436* stop_gained 1.00 0
16:68822075:T E596* stop_gained 1.00 0
16:68808496:T R154* stop_gained 1.00 0
16:68808714:T E185* stop_gained 1.00 0
16:68815749:T Q519* stop_gained 1.00 0
16:68810255:A L249* stop_gained 1.00 0
16:68808448:T E138* stop_gained 1.00 0
16:68812183:T E353* stop_gained 1.00 0
16:68815718:G Y508* stop_gained 1.00 0
16:68815718:A Y508* stop_gained 1.00 0
16:68823452:T K664* stop_gained 1.00 0
16:68808711:T K184* stop_gained 1.00 0
16:68811779:T E310* stop_gained 1.00 0
16:68833488:T E880* stop_gained 1.00 0
16:68823437:T E659* stop_gained 1.00 0
16:68801710:G Y68* stop_gained 1.00 0
16:68828274:G Y755* stop_gained 1.00 0
16:68828274:A Y755* stop_gained 1.00 0
16:68823404:T E648* stop_gained 1.00 0
16:68822215:A Y642* stop_gained 1.00 0
16:68822215:G Y642* stop_gained 1.00 0
16:68833435:A L862* stop_gained 1.00 0
16:68738332:A C28* stop_gained 1.00 0
16:68823520:A C686* stop_gained 1.00 0
16:68813337:T E388* stop_gained 1.00 0
16:68823451:A Y663* stop_gained 1.00 0
16:68823451:G Y663* stop_gained 1.00 0
16:68810311:T K268* stop_gained 1.00 0
16:68833478:A Y876* stop_gained 1.00 0
16:68801809:A Y101* stop_gained 1.00 0
16:68801809:G Y101* stop_gained 1.00 0
16:68737426:A W4* stop_gained 1.00 0
16:68833478:G Y876* stop_gained 1.00 0
16:68833331:A Y827* stop_gained 1.00 0
16:68833331:G Y827* stop_gained 1.00 0
16:68811791:T K314* stop_gained 1.00 0
16:68801802:A L99* stop_gained 1.00 0
16:68737427:A W4* stop_gained 1.00 0
16:68813403:T E410* stop_gained 1.00 0
16:68813316:T K381* stop_gained 1.00 0
16:68819374:T E554* stop_gained 1.00 0
16:68823547:A C695* stop_gained 1.00 0
16:68833427:G Y859* stop_gained 1.00 0
16:68833427:A Y859* stop_gained 1.00 0
16:68833355:G Y835* stop_gained 1.00 0
16:68810302:T E265* stop_gained 1.00 0
16:68823491:T Q677* stop_gained 1.00 0
16:68823621:A L720* stop_gained 1.00 0
16:68811857:T E336* stop_gained 1.00 0
16:68811757:A Y302* stop_gained 1.00 0
16:68811757:G Y302* stop_gained 1.00 0
16:68822174:T E629* stop_gained 1.00 0
16:68813322:T Q383* stop_gained 1.00 0
16:68828176:T L723L splice_region_variant 1.00 0
16:68815527:T E445* stop_gained 1.00 0
16:68823417:A L652* stop_gained 1.00 0
16:68808813:T E218* stop_gained 1.00 0
16:68813315:A Y380* stop_gained 1.00 0
16:68813315:G Y380* stop_gained 1.00 0
16:68815746:T E518* stop_gained 1.00 0
16:68829749:A Y797* stop_gained 1.00 0
16:68829749:G Y797* stop_gained 1.00 0
16:68815519:A L442* stop_gained 1.00 0
16:68823526:A C688* stop_gained 1.00 0
16:68810299:T Q264* stop_gained 1.00 0
16:68738408:T R54* stop_gained 1.00 0
16:68808529:T E165* stop_gained 1.00 0
16:68810248:T E247* stop_gained 1.00 0
16:68828192:A L728* stop_gained 1.00 0
16:68823504:G L681* stop_gained 0.99 0
16:68823435:A L658* stop_gained 0.99 0
16:68823435:G L658* stop_gained 0.99 0
16:68823504:A L681* stop_gained 0.99 0
16:68808493:T K153* stop_gained 0.99 0
16:68819310:A W532* stop_gained 0.99 0
16:68819309:A W532* stop_gained 0.99 0
16:68801671:C V55V splice_region_variant 0.99 0
16:68801671:A V55V splice_region_variant 0.99 0
16:68801671:T V55V splice_region_variant 0.99 0
16:68812263:T T379T splice_region_variant 0.99 0
16:68812263:C T379T splice_region_variant 0.99 0
16:68810340:C P277P splice_region_variant 0.99 0
16:68810340:T P277P splice_region_variant 0.99 0
16:68810340:G P277P splice_region_variant 0.99 0
16:68822224:T P645P splice_region_variant 0.99 0
16:68822224:G P645P splice_region_variant 0.99 0
16:68822224:C P645P splice_region_variant 0.99 0
16:68738410:G R54R splice_region_variant 0.99 0
16:68737463:A Q16Q splice_region_variant 0.99 0
16:68833292:C N814N splice_region_variant 0.99 0
16:68815752:T K520* stop_gained 0.99 0
16:68823605:T G715* stop_gained 0.99 0
16:68822018:T G577* stop_gained 0.99 0
16:68833461:T K871* stop_gained 0.99 0
16:68810326:T E273* stop_gained 0.99 0
16:68829797:G E813E splice_region_variant 0.99 0
16:68815728:T E512* stop_gained 0.99 0
16:68810236:T E243* stop_gained 0.99 0
16:68808504:A W156* stop_gained 0.99 0
16:68808503:A W156* stop_gained 0.99 0
16:68815638:T E482* stop_gained 0.99 0
16:68808747:T G196* stop_gained 0.99 0
16:68815683:T E497* stop_gained 0.99 0
16:68808795:T G212* stop_gained 0.99 0
16:68808828:T E223* stop_gained 0.99 0
16:68828278:T E757* stop_gained 0.99 0
16:68828284:T G759* stop_gained 0.99 0
16:68828290:T G761* stop_gained 0.99 0
16:68828293:T E762* stop_gained 0.99 0
16:68828296:T E763* stop_gained 0.99 0
16:68829699:T E781* stop_gained 0.99 0
16:68833356:T E836* stop_gained 0.99 0
16:68833359:T G837* stop_gained 0.99 0
16:68833444:A W865* stop_gained 0.99 0
16:68833445:A W865* stop_gained 0.99 0
16:68811821:T G324* stop_gained 0.99 0
16:68833479:T G877* stop_gained 0.99 0
16:68808695:A I178I splice_region_variant 0.99 0
16:68808695:T I178I splice_region_variant 0.99 0
16:68810199:A L230L splice_region_variant 0.99 0
16:68810199:T L230L splice_region_variant 0.99 0
16:68810199:G L230L splice_region_variant 0.99 0
16:68822202:A W638* stop_gained 0.99 0
16:68822203:A W638* stop_gained 0.99 0
16:68815757:C I521I splice_region_variant 0.99 0
16:68815757:T I521I splice_region_variant 0.99 0
16:68819280:G T522T splice_region_variant 0.99 0
16:68819280:T T522T splice_region_variant 0.99 0
16:68819280:C T522T splice_region_variant 0.99 0
16:68829656:T D766D splice_region_variant 0.90 0
16:68823400:G T646T splice_region_variant 0.89 0
16:68823400:A T646T splice_region_variant 0.89 0
16:68823400:T T646T splice_region_variant 0.89 0
16:68808848:C T229T splice_region_variant 0.88 0
16:68808848:A T229T splice_region_variant 0.88 0
16:68808848:G T229T splice_region_variant 0.88 0
16:68808426:G A130A splice_region_variant 0.88 0
16:68808426:A A130A splice_region_variant 0.88 0
16:68808426:T A130A splice_region_variant 0.88 0
16:68811685:T G278G splice_region_variant 0.88 0
16:68811685:G G278G splice_region_variant 0.88 0
16:68811685:C G278G splice_region_variant 0.88 0
16:68738299:T V17V splice_region_variant 0.87 0
16:68738299:G V17V splice_region_variant 0.87 0
16:68738299:A V17V splice_region_variant 0.87 0
16:68819424:C N570N splice_region_variant 0.87 0
16:68801893:A Q129Q splice_region_variant 0.86 0
16:68823625:C L721L splice_region_variant 0.86 0
16:68823625:T L721L splice_region_variant 0.86 0
16:68823625:G L721L splice_region_variant 0.86 0
16:68812137:C S337S splice_region_variant 0.86 0
16:68828175:C I722I splice_region_variant 0.86 0
16:68828175:A I722I splice_region_variant 0.86 0
16:68813315:T Y380Y splice_region_variant 0.85 0
16:68822002:A G571G splice_region_variant 0.85 0
16:68822002:G G571G splice_region_variant 0.85 0
16:68822002:C G571G splice_region_variant 0.85 0
16:68815517:T G441G splice_region_variant 0.85 0
16:68815517:A G441G splice_region_variant 0.85 0
16:68815517:G G441G splice_region_variant 0.85 0
In silico saturation mutagenesis
Alt text Show figure caption
Cancer type Selected cancer type Mutational discovery Index Feature Complexity
(BRCA) Breast adenocarcinoma BRCA 0.24 0.14