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CDKN2A 9:21971018:C (P114R) × LUSC ×
Driver potential information
Model BoostDM class BoostDM score
(LUSC) Lung squamous cell carcinoma Driver 0.99
Feature importance

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Feature Feature value SHAP value
Linear Clustering Score (LCS) 229.98 0.18 Medium positive
Linear Clustering in Cancer Type (LCT) 0.00 0.00 Non-significant
Linear Clustering (LC) 1.00 -0.02 Non-significant
3D Clustering in Cancer Type (3CT) 1.00 0.81 Medium positive
3D clustering (3C) 0.00 0.00 Non-significant
Recurrent in PFAM Domain (DOM) 0.00 0.00 Non-significant
Recurrent in PFAM Domain v2 (DOM2) 0.00 0.00 Non-significant
PhyloP 100-way Score (PHYLOP) 9.18 1.14 High positive
Stop Codon in Last Exon (NMD) 0.00 0.00 Non-significant
Post-translational Modification Site: Acetylation (ACETYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Methylation (METHYLATION) 0.00 0.00 Non-significant
Post-translational Modification Site: Phosphorylation (PHOS) 0.00 0.00 Non-significant
Post-translational Modification Site: Regulatory site (REG) 0.00 0.00 Non-significant
Post-translational Modification Site: Ubiquitination (UB) 0.00 0.00 Non-significant
Consequence Type: Missense (MISSENSE) 1.00 0.06 Non-significant
Consequence Type: Nonsense (NONSENSE) 0.00 -0.31 Medium negative
Consequence Type: Splice-affecting (SPLICE) 0.00 0.00 Non-significant
Consequence Type: Synonymous (SYNONYMOUS) 0.00 0.00 Non-significant